MSC-4381 (MCT4-IN-1) is an orally active, selective inhibitor of monocarboxylate transporter 4 (MCT4) with an IC50 of 77 nM and a Ki of 11 nM. It has the potential to inhibit lactate efflux and promote intracellular lactate accumulation in MCT4-expressing cell lines.

MSC-4381 (MCT4-IN-1) is an orally active, selective inhibitor of monocarboxylate transporter 4 (MCT4) with an IC50 of 77 nM and a Ki of 11 nM. It has the potential to inhibit lactate efflux and promote intracellular lactate accumulation in MCT4-expressing cell lines.

MSC-4381 (MCT4-IN-1) is an orally active, selective inhibitor of monocarboxylate transporter 4 (MCT4) with an IC50 of 77 nM and a Ki of 11 nM. It has the potential to inhibit lactate efflux and promote intracellular lactate accumulation in MCT4-expressing cell lines.

MSC-4381 (MCT4-IN-1) is an orally active, selective inhibitor of monocarboxylate transporter 4 (MCT4) with an IC50 of 77 nM and a Ki of 11 nM. It has the potential to inhibit lactate efflux and promote intracellular lactate accumulation in MCT4-expressing cell lines.

Ulonivirine(MK-8507) is a selective and potent inhibitor of HIV-1 nonnucleoside reverse transcriptase (NNRTI) that binds to the classic NNRTI hydrophobic binding pocket near the polymerase active site. It demonstrates a potential to treat HIV-1 infections and induce the expression of CYP3A4, an enzyme often involved in drug metabolism.

Ulonivirine(MK-8507) is a selective and potent inhibitor of HIV-1 nonnucleoside reverse transcriptase (NNRTI) that binds to the classic NNRTI hydrophobic binding pocket near the polymerase active site. It demonstrates a potential to treat HIV-1 infections and induce the expression of CYP3A4, an enzyme often involved in drug metabolism.

Ulonivirine(MK-8507) is a selective and potent inhibitor of HIV-1 nonnucleoside reverse transcriptase (NNRTI) that binds to the classic NNRTI hydrophobic binding pocket near the polymerase active site. It demonstrates a potential to treat HIV-1 infections and induce the expression of CYP3A4, an enzyme often involved in drug metabolism.

Ulonivirine(MK-8507) is a selective and potent inhibitor of HIV-1 nonnucleoside reverse transcriptase (NNRTI) that binds to the classic NNRTI hydrophobic binding pocket near the polymerase active site. It demonstrates a potential to treat HIV-1 infections and induce the expression of CYP3A4, an enzyme often involved in drug metabolism.

Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect.

Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective inhibitor of MALT1 protease, with IC50 values of 0.83 μM for GSTMALT1 full length and 0.42 μM for GSTMALT1 aa 325-760. It effectively suppresses the activation of the NF-kB pathway specifically in activated B cell subtype of diffuse large B cell lymphoma (ABC-DLBCL) cells and makes […]