Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a selective and potent inhibitor of pan-class I PI3K. It significantly inhibits the catalytic activity of class I PI3K isoforms α, β, γ, and δ with IC50 of 0.5, 3.7, 6.4, and 0.7 nM, respectively. BAY 80-6946 exhibits potent antitumor activity in multiple cell-line–derived and patient-derived xenograft tumor models.

Monzosertib (AS-0141) is a potent, selective, orally bioavailable inhibitor of CDC7 with an IC50 2.4 nM. It demonstrates antitumor efficacy and can be used in research to study treatments for advanced, metastatic, relapsed, or refractory malignancies, including acute myeloid leukemia (AML) and solid tumors.

Monzosertib (AS-0141) is a potent, selective, orally bioavailable inhibitor of CDC7 with an IC50 2.4 nM. It demonstrates antitumor efficacy and can be used in research to study treatments for advanced, metastatic, relapsed, or refractory malignancies, including acute myeloid leukemia (AML) and solid tumors.

Monzosertib (AS-0141) is a potent, selective, orally bioavailable inhibitor of CDC7 with an IC50 2.4 nM. It demonstrates antitumor efficacy and can be used in research to study treatments for advanced, metastatic, relapsed, or refractory malignancies, including acute myeloid leukemia (AML) and solid tumors.

Monzosertib (AS-0141) is a potent, selective, orally bioavailable inhibitor of CDC7 with an IC50 2.4 nM. It demonstrates antitumor efficacy and can be used in research to study treatments for advanced, metastatic, relapsed, or refractory malignancies, including acute myeloid leukemia (AML) and solid tumors.

VLS-1488 (KIF18A-IN-6) is an oral inhibitor of KIF18A with an IC50 of 0.016 μM. KIF18A is a mitotic kinesin motor protein that localizes at the plus-end of kinetochore microtubule spindle fibers and is crucial for cell division in aneuploid cancer cells with high chromosomal instability (CIN).

VLS-1488 (KIF18A-IN-6) is an oral inhibitor of KIF18A with an IC50 of 0.016 μM. KIF18A is a mitotic kinesin motor protein that localizes at the plus-end of kinetochore microtubule spindle fibers and is crucial for cell division in aneuploid cancer cells with high chromosomal instability (CIN).

VLS-1488 (KIF18A-IN-6) is an oral inhibitor of KIF18A with an IC50 of 0.016 μM. KIF18A is a mitotic kinesin motor protein that localizes at the plus-end of kinetochore microtubule spindle fibers and is crucial for cell division in aneuploid cancer cells with high chromosomal instability (CIN).

VLS-1488 (KIF18A-IN-6) is an oral inhibitor of KIF18A with an IC50 of 0.016 μM. KIF18A is a mitotic kinesin motor protein that localizes at the plus-end of kinetochore microtubule spindle fibers and is crucial for cell division in aneuploid cancer cells with high chromosomal instability (CIN).

BGB-3245(Brimarafenib, Brimarafenibum) is an inhibitor of Raf kinase. BGB-3245 displays potent effects against different RAF isoforms, including BRAF Class I/II/III mutations, BRAF fusions, and heterodimerization with CRAF in preclinical models. It also exhibits antineoplastic effects.