Edpetiline is a steroidal alkaloid derived from Fritillaria species that exhibits potent anti-inflammatory and antioxidant effects. It suppresses proinflammatory mediators and reactive oxygen species (ROS) production while inhibiting NF-κB nuclear translocation and selectively blocking p38 and ERK MAPK phosphorylation.

N-Hexanoyl-L-homoserine lactone is a mediator of bacterial quorum-sensing(QS) regulation and used as a QS signal molecule by many different Gram-negative bacteria. It also allows the transcription of the regulated genes.

Varoglutamstat (PQ912) is an inhibitor of glutaminyl cyclase (QC), inhibiting human glutaminyl cyclase (hQC) activity with a Ki of 25 nM (pH 8.0). It reduces pyroglutamyl-Aβ (pE-Aβ) levels and can be used in Alzheimer’s disease research.

AKR1C3-IN-1 is a highly potent inhibitor of aldo-keto reductaseAKR1C3 with an IC50 of 13 nM. It can be used in research targeting both breast and prostate cancer.

Benzylamiloride hydrochloride (Benzamil hydrochloride) is an inhibitor of Na+/Ca2+ exchanger (NCX) with an IC50 ~100 nM. It reduces hyponatremic brain edema by blocking sodium influx in vivo.

TAK-779(Takeda 779), a nonpeptide compound,  is a potent antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5. It also exhibits highly potent and selective inhibition of R5 HIV-1 replication with EC50 and EC90 of 1.2 and 5.7 nM, respectively. It also suppresses the development of the cytokine storm in the murine model of […]