PD150606 is a potent and selective inhibitor of calpainwith Ki values of 0.21 µM for µ-calpain and 0.37 µM for m-calpain. It exhibits neuroprotective effects by reducing hypoxic/hypoglycemic injury in cerebrocortical neurons and excitotoxic damage in cerebellar Purkinje cells.

SEW2871 is an orally active, potent, and highly selective agonist of the sphingosine-1-phosphate type 1 receptor (S1P1) with an EC50 of 13.8 nM. It activates ERK, Akt, and Rac signalling pathways and induces S1P1 internalization and recycling.

Refametinib R enantiomer is a MEK inhibitor extracted from patent WO2007014011A2, compound 1022, has an EC50 of 2.0-15 nM.

W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM. It may exhibit potential clinical applications in multiple sclerosis, coronary artery disease, diabetes, and cancer treatment.

BAY 1000394 (Roniciclib) is a potent inhibitor of pan-CDK, that inhibits the kinase activity of the cell-cycle cyclin-dependent kinases (CDKs), with IC50 of 7, 9, 11, 25 and 5 nmol/L for CDK1, CDK2, CDK4, CDK7 and CDK9, respectively. It induces cell-cycle arrest and apoptosis and exhibits potent antitumor activity.

Calcium chloride (CaCl2) is an ionic compound used for calcium supplementation in conditions like hypocalcemia and hyperkalemia and as an antidote for magnesium toxicity. It also functions as a co-adjuvant in hemostatic formulations and effectively treats refractory hypotension and complete heart block. It enhances the activity of MoPtc1 and MoPtc2, type 2C protein phosphatases involved […]

Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .