GSK864 is a cell-penetrant, potent, and selective inhibitor of isocitrate dehydrogenase 1 (IDH1) mutants, specifically targeting the R132C, R132H, and R132G variants with IC50 values of 8.8 nM, 15.2 nM, and 16.6 nM, respectively.

Deferoxamine (Deferoxamine B, Deferrioxamine) is an iron chelator and a reversible inhibitor of S-phase in DNA synthesis. It enhnaces HIF-1α activation by inhibiting prolyl hydroxylase activity, activating insulin receptor (InsR) and Glut1. It also increases phosphorylation of Akt/PKB, FoxO1, GSK3β, influencing gluconeogenesis and glycogen synthesis, while reducing oxidative stress in diabetic hyperglycemia. It can be […]

Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research-.

CHZ868 is an inhibitor of type II JAK2 with an IC50 value of 0.17 μM in EPOR JAK2 WT Ba/F3 cells. CHZ868 demonstrates 60- to 70-fold higher inhibition of JAK1-/TYK2-mediated nuclear STAT1 translocation compared to pan-JAK inhibitors.

Tin Protoporphyrin IX dichloride (NSC 267099, SnPPIX, Sn-Protoporphyrin) is a potent inhibitor of heme oxygenase-1 (HO-1), reduces ozone-induced pulmonary inflammation and BAL cell necrosis, highlighting its protective role. It also sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in a mouse model, suggesting its potential for PDAC treatment.