H3B-8800 is a potent and orally active modulator of SF3B splicing. H3B-8800 interacts directly with the SF3b complex, demonstrating anti-cancer properties. H3B-8800 holds promise for studying acute myeloid leukemia (AML) with SF3B1 mutations.

H3B-8800 is a potent and orally active modulator of SF3B splicing. H3B-8800 interacts directly with the SF3b complex, demonstrating anti-cancer properties. H3B-8800 holds promise for studying acute myeloid leukemia (AML) with SF3B1 mutations.

H3B-8800 is a potent and orally active modulator of SF3B splicing. H3B-8800 interacts directly with the SF3b complex, demonstrating anti-cancer properties. H3B-8800 holds promise for studying acute myeloid leukemia (AML) with SF3B1 mutations.

PF-06821497 is a selective and orally active inhibitor of Zeste Homolog 2 (EZH2) with a Ki value

Nelfinavir (AG-1341) is a potent inhibitor of HIV protease and induces endoplasmic reticulum (ER) stress, autophagy, and apoptosis in vitro and in vivo. It also inhibits Streptolysin S (SLS) production, a key virulence factor of Streptococcus pyogenes, with IC50 of 6 µM.

Tipranavir(PNU-140690) is a nonpeptidyl inhibitor of HIV protease with high potency Ki of 0.008 nM and IC50 of 0.03 μM, it also inhibited HIV-2 protease with Ki of < 1 nM. It is administered in combination antiretroviral therapy to treat HIV-1 infection and AIDS.

Nelfinavir (AG-1341) is a potent inhibitor of HIV protease and induces endoplasmic reticulum (ER) stress, autophagy, and apoptosis in vitro and in vivo. It also inhibits Streptolysin S (SLS) production, a key virulence factor of Streptococcus pyogenes, with IC50 of 6 µM.

Vigabatrin (γ-Vinyl-GABA) is an orally active, irreversible inhibitor of GABA transaminase, increasing brain GABA levels by blocking its breakdown. It is an antiepileptic drug that enhances inhibitory neurotransmission to control seizures and exhibits potential in treating partial seizures, infantile spasms, and Lennox-Gastaut syndrome.

Vigabatrin (γ-Vinyl-GABA) is an orally active, irreversible inhibitor of GABA transaminase, increasing brain GABA levels by blocking its breakdown. It is an antiepileptic drug that enhances inhibitory neurotransmission to control seizures and exhibits potential in treating partial seizures, infantile spasms, and Lennox-Gastaut syndrome.