SDU-071 is an inhibitor of BRD4-p53 protein-protein interaction with IC50 of 2.7 μM, which suppresses MDA-MB-231 triple-negative breast cancer (TNBC) cell migration, invasion, and in vivo tumor growth. It also exhibits antiproliferative activity in concentration concentration-dependent manner, with IC50 of 10.5 μM (72 h) and 12.6 μM (96 h) in MDA-MB-231 cells.

MS-L6(Agn-PC-0N3ahi, NSC34338) is a potent inhibitor of OXPHOS, targeting electron transport chain complexes I (ETC-I), combining inhibition of NADH oxidation and uncoupling effect, on the respiratory chain. It exhibits potent antitumor efficacy.

KHK-6 is a potent ATP-competitive inhibitor of HPK1 kinase activity with an IC50 value of 20 nM. It significantly enhances CD3/CD28-induced production of cytokines by downregulating the HPK1-SLP-76 signaling cascade in the TCR signaling pathway.

KHK-6 is a potent ATP-competitive inhibitor of HPK1 kinase activity with an IC50 value of 20 nM. It significantly enhances CD3/CD28-induced production of cytokines by downregulating the HPK1-SLP-76 signaling cascade in the TCR signaling pathway.

MS-L6(Agn-PC-0N3ahi, NSC34338) is a potent inhibitor of OXPHOS, targeting electron transport chain complexes I (ETC-I), combining inhibition of NADH oxidation and uncoupling effect, on the respiratory chain. It exhibits potent antitumor efficacy.

MS-L6(Agn-PC-0N3ahi, NSC34338) is a potent inhibitor of OXPHOS, targeting electron transport chain complexes I (ETC-I), combining inhibition of NADH oxidation and uncoupling effect, on the respiratory chain. It exhibits potent antitumor efficacy.

Etoposide phosphate a phosphate ester proagent of etoposide, is a selective inhibitor of topoisomerase II and a potent anti-cancer chemotherapy agent. Etoposide phosphate also induces cell cycle arrest, apoptosis, and autophagy.

MS-L6(Agn-PC-0N3ahi, NSC34338) is a potent inhibitor of OXPHOS, targeting electron transport chain complexes I (ETC-I), combining inhibition of NADH oxidation and uncoupling effect, on the respiratory chain. It exhibits potent antitumor efficacy.

Etoposide phosphate a phosphate ester proagent of etoposide, is a selective inhibitor of topoisomerase II and a potent anti-cancer chemotherapy agent. Etoposide phosphate also induces cell cycle arrest, apoptosis, and autophagy.

Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level.