NNK is a potent carcinogen formed by nitrosation of nicotine that promotes survival and proliferation of human lung cancer cells. It activates ERK1/2 and PKCα, leading to Bcl2 and c-Myc phosphorylation, which may contribute to lung cancer development and chemoresistance and can be used for lung cancer mice model structure.

FOT1 (CN128, CN328) hydrochloride is a potent and orally active hydroxypyridinone iron chelator with potential for treating systemic iron overload and β-thalassemia. It also helps prevent the onset and slows early-stage Parkinson’s disease symptoms by reducing oxidants and toxic intermediates from iron-mediated dopamine oxidation.

FOT1 (CN128, CN328) hydrochloride is a potent and orally active hydroxypyridinone iron chelator with potential for treating systemic iron overload and β-thalassemia. It also helps prevent the onset and slows early-stage Parkinson’s disease symptoms by reducing oxidants and toxic intermediates from iron-mediated dopamine oxidation.

FOT1 (CN128, CN328) hydrochloride is a potent and orally active hydroxypyridinone iron chelator with potential for treating systemic iron overload and β-thalassemia. It also helps prevent the onset and slows early-stage Parkinson’s disease symptoms by reducing oxidants and toxic intermediates from iron-mediated dopamine oxidation.

MYC-IN-3 (Cpd. 37) is an alkynyl-substituted phenylpyrazole derivative and an inhibitor of MYC function by disrupting MYC/MAX interaction with an IC50 of 1.27 μM in PC3 cells and preventing MYC/MAX binding to DNA. It exhibits antiproliferative activity against multiple malignant cell lines and demonstrates enhanced therapeutic efficacy in a mouse allograft model of prostate cancer.

MYC-IN-3 (Cpd. 37) is an alkynyl-substituted phenylpyrazole derivative and an inhibitor of MYC function by disrupting MYC/MAX interaction with an IC50 of 1.27 μM in PC3 cells and preventing MYC/MAX binding to DNA. It exhibits antiproliferative activity against multiple malignant cell lines and demonstrates enhanced therapeutic efficacy in a mouse allograft model of prostate cancer.

MYC-IN-3 (Cpd. 37) is an alkynyl-substituted phenylpyrazole derivative and an inhibitor of MYC function by disrupting MYC/MAX interaction with an IC50 of 1.27 μM in PC3 cells and preventing MYC/MAX binding to DNA. It exhibits antiproliferative activity against multiple malignant cell lines and demonstrates enhanced therapeutic efficacy in a mouse allograft model of prostate cancer.

MYC-IN-3 (Cpd. 37) is an alkynyl-substituted phenylpyrazole derivative and an inhibitor of MYC function by disrupting MYC/MAX interaction with an IC50 of 1.27 μM in PC3 cells and preventing MYC/MAX binding to DNA. It exhibits antiproliferative activity against multiple malignant cell lines and demonstrates enhanced therapeutic efficacy in a mouse allograft model of prostate cancer.

BI-9787 is a potent zwitterion inhibitor of ketohexokinase(KHK) with IC50 values of 12 nM and 12.8 nM for hKHK-A and hKHK-C. It exhibits good metabolic stability in rat hepatocytes and serves as a potent tool compound for in vitro and in vivo studies in rodents.

BI-9787 is a potent zwitterion inhibitor of ketohexokinase(KHK) with IC50 values of 12 nM and 12.8 nM for hKHK-A and hKHK-C. It exhibits good metabolic stability in rat hepatocytes and serves as a potent tool compound for in vitro and in vivo studies in rodents.