DBCO-PEGn-VA-PAB is a cleavable PEG-containing ADC linker for the development of antibody-coupled drugs (ADCs). Val-Ala can be specifically cleaved by histone B; DBCO (dibenzocyclooctyne) groups are commonly used in copper-free click chemistry; and hydrophilic PEG spacer groups improve the water solubility of compounds.

DBCO-PEGn-VC-PAB is a cleavable PEG-containing ADC linker for the development of antibody-coupled drugs (ADCs). The Val-Cit can be specifically cleaved by histone B; the DBCO (dibenzocyclooctyne) moiety is typically used for copper-free click chemistry; and the hydrophilic PEG spacer group improves the water solubility of the compound.

DBCO-PEGn-VC-PAB is a cleavable PEG-containing ADC linker for the development of antibody-coupled drugs (ADCs). The Val-Cit can be specifically cleaved by histone B; the DBCO (dibenzocyclooctyne) moiety is typically used for copper-free click chemistry; and the hydrophilic PEG spacer group improves the water solubility of the compound.

DBCO-PEGn-VC-PAB is a cleavable PEG-containing ADC linker for the development of antibody-coupled drugs (ADCs). The Val-Cit can be specifically cleaved by histone B; the DBCO (dibenzocyclooctyne) moiety is typically used for copper-free click chemistry; and the hydrophilic PEG spacer group improves the water solubility of the compound.

DBCO-PEGn-VC-PAB is a cleavable PEG-containing ADC linker for the development of antibody-coupled drugs (ADCs). The Val-Cit can be specifically cleaved by histone B; the DBCO (dibenzocyclooctyne) moiety is typically used for copper-free click chemistry; and the hydrophilic PEG spacer group improves the water solubility of the compound.

ALKYNE-PEGn-SPA is a non-cleavable PEG-containing ADC linker for the development of antibody-coupled drugs (ADCs).

DBCO-PEGn-VC-PAB is a cleavable PEG-containing ADC linker for the development of antibody-coupled drugs (ADCs). The Val-Cit can be specifically cleaved by histone B; the DBCO (dibenzocyclooctyne) moiety is typically used for copper-free click chemistry; and the hydrophilic PEG spacer group improves the water solubility of the compound.

HO-PEG4-ALKYNE is a non-cleavable PEG-containing ADC linker for the development of antibody-coupled drugs (ADCs).

ALKYNE-PEGn-SPA is a non-cleavable PEG-containing ADC linker for the development of antibody-coupled drugs (ADCs).

AZIDE-PEGn-CM is a non-cleavable PEG-containing ADC linker for the development of antibody-coupled drugs (ADCs).