Gypenoside L, is a saponin from Gynostemma pentaphyllum, increases SA-β-galactosidase activity, enhances senescence-associated cytokine production, inhibits proliferation and LPS-induced nitric oxide (NO) production, induces S-phase arrest, and activates p21, p27, p38, ERK MAPK, and NF-κB pathways to promote senescence.

Gypenoside L, is a saponin from Gynostemma pentaphyllum, increases SA-β-galactosidase activity, enhances senescence-associated cytokine production, inhibits proliferation and LPS-induced nitric oxide (NO) production, induces S-phase arrest, and activates p21, p27, p38, ERK MAPK, and NF-κB pathways to promote senescence.

Gypenoside L, is a saponin from Gynostemma pentaphyllum, increases SA-β-galactosidase activity, enhances senescence-associated cytokine production, inhibits proliferation and LPS-induced nitric oxide (NO) production, induces S-phase arrest, and activates p21, p27, p38, ERK MAPK, and NF-κB pathways to promote senescence.

DC_AC50 is an inhibitor of the copper-trafficking proteins Atox1 (kd ∼6.8 µM) and full-length CCS (kd ∼8.2 µM) that significantly suppressing cell proliferation in various human cancer cell lines.

BIO-2007817 is a tetrahydropyrazolo-pyrazine and a positive allosteric modulator(PAM) that can act as a molecular glue to enhance the ability of pUb to activate Parkin with an EC50 of 150 nM. It can be used in research design of activators as therapeutics for Parkinson’s disease.

BIO-2007817 is a tetrahydropyrazolo-pyrazine and a positive allosteric modulator(PAM) that can act as a molecular glue to enhance the ability of pUb to activate Parkin with an EC50 of 150 nM. It can be used in research design of activators as therapeutics for Parkinson’s disease.

BIO-2007817 is a tetrahydropyrazolo-pyrazine and a positive allosteric modulator(PAM) that can act as a molecular glue to enhance the ability of pUb to activate Parkin with an EC50 of 150 nM. It can be used in research design of activators as therapeutics for Parkinson’s disease.

Indolelactic acid (Indole-3-lactic acid), a metabolite of tryptophan (Trp), plays a role in immune cell differentiation and cytokine production by activating aryl hydrocarbon receptors (AhR). This regulation supports immune responses and aids in anti-inflammatory and anti-allergic activities. It also plays an important role in the balance of Th17/Treg cells by reprogramming CD4+ Th cells into CD4+CD8+ Treg […]

BIO-2007817 is a tetrahydropyrazolo-pyrazine and a positive allosteric modulator(PAM) that can act as a molecular glue to enhance the ability of pUb to activate Parkin with an EC50 of 150 nM. It can be used in research design of activators as therapeutics for Parkinson’s disease.