Heparin is a highly sulfated polysaccharide primarily used as an anticoagulant, which works mainly by inhibiting thrombin (FIIa) and/or factor Xa (FXa). It is commonly used to prevent and treat thromboembolic conditions such as deep vein thrombosis and pulmonary embolism. It also plays roles in inflammation, angiogenesis, and growth factor signaling, with potential therapeutic applications […]

DFP00173 is a selective and potent inhibitor of Aquaporin-3 (AQP3), it inhibits mouse and human AQP3 with an IC50 of ∼0.1 μM–0.4 μM. It demonstrates potential for treating human disorders of water retention.

DFP00173 is a selective and potent inhibitor of Aquaporin-3 (AQP3), it inhibits mouse and human AQP3 with an IC50 of ∼0.1 μM–0.4 μM. It demonstrates potential for treating human disorders of water retention.

DFP00173 is a selective and potent inhibitor of Aquaporin-3 (AQP3), it inhibits mouse and human AQP3 with an IC50 of ∼0.1 μM–0.4 μM. It demonstrates potential for treating human disorders of water retention.

KN-93 hydrochloride is a methoxybenzenesulfonamide derivative that inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 0.37 µM. It reduces dopamine (DA) production by influencing the reaction rate of tyrosine hydroxylase (TH), leading to decreased Ca(2+)-mediated phosphorylation of the TH protein.

KN-93 hydrochloride is a methoxybenzenesulfonamide derivative that inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 0.37 µM. It reduces dopamine (DA) production by influencing the reaction rate of tyrosine hydroxylase (TH), leading to decreased Ca(2+)-mediated phosphorylation of the TH protein.

DFP00173 is a selective and potent inhibitor of Aquaporin-3 (AQP3), it inhibits mouse and human AQP3 with an IC50 of ∼0.1 μM–0.4 μM. It demonstrates potential for treating human disorders of water retention.

PU139 is a potent inhibitor of pan-histone acetyltransferase (HAT) that blocks Gcn5, PCAF, CBP, and p300 with IC50 values of 8.39 μM, 9.74 μM, 2.49 μM, and 5.35 μM, respectively. It significantly impairs Smp14 promoter activity, suggesting that targeting SmGCN5 and SmCBP1 is a novel strategy to control S. mansoni egg development, it also exhibits […]

KN-93 hydrochloride is a methoxybenzenesulfonamide derivative that inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 0.37 µM. It reduces dopamine (DA) production by influencing the reaction rate of tyrosine hydroxylase (TH), leading to decreased Ca(2+)-mediated phosphorylation of the TH protein.

KN-93 hydrochloride is a methoxybenzenesulfonamide derivative that inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 0.37 µM. It reduces dopamine (DA) production by influencing the reaction rate of tyrosine hydroxylase (TH), leading to decreased Ca(2+)-mediated phosphorylation of the TH protein.