Necrocide1 is a potent inducer of cancer cell necrosis and displays antiproliferative activity with IC50 values of 0.48 nM and 2 nM for MCF-7 and PC3 cells, respectively. Necrocide1 also exerts potent antitumor effects in xenograft models.

LYG-409 is a potent, selective, and orally bioavailable degrader of GSPT1, with a DC50 of 7.87 nM. It exhibits strong antiproliferative activity in KG-1 cells with an IC50 of 9.50 nM and demonstrates significant antitumor efficacy in vivo in models of acute myeloid leukemia and prostate cancer.

LYG-409 is a potent, selective, and orally bioavailable degrader of GSPT1, with a DC50 of 7.87 nM. It exhibits strong antiproliferative activity in KG-1 cells with an IC50 of 9.50 nM and demonstrates significant antitumor efficacy in vivo in models of acute myeloid leukemia and prostate cancer.

LYG-409 is a potent, selective, and orally bioavailable degrader of GSPT1, with a DC50 of 7.87 nM. It exhibits strong antiproliferative activity in KG-1 cells with an IC50 of 9.50 nM and demonstrates significant antitumor efficacy in vivo in models of acute myeloid leukemia and prostate cancer.

LL-K12-18 is a potent dual-site molecular glue that enhances CDK12-DDB1 complex formation, promoting cyclin K degradation with an EC50 of 0.37 nM. It also demonstrates strong inhibition of gene transcription and anti-proliferative effects in tumor cells, exhibiting significant potential in cancer research.

LYG-409 is a potent, selective, and orally bioavailable degrader of GSPT1, with a DC50 of 7.87 nM. It exhibits strong antiproliferative activity in KG-1 cells with an IC50 of 9.50 nM and demonstrates significant antitumor efficacy in vivo in models of acute myeloid leukemia and prostate cancer.

LL-K12-18 is a potent dual-site molecular glue that enhances CDK12-DDB1 complex formation, promoting cyclin K degradation with an EC50 of 0.37 nM. It also demonstrates strong inhibition of gene transcription and anti-proliferative effects in tumor cells, exhibiting significant potential in cancer research.

LY294002 hydrochloride is a potent and specific inhibitor of PI3K with an IC50 of 0.5 μM, 0.97 μM, and 0.57 μM for P110α, P110β, P110δ, respectively. It also acts as a direct blocker of L-type Ca2+ channel with IC50 of 20 µM.

LL-K12-18 is a potent dual-site molecular glue that enhances CDK12-DDB1 complex formation, promoting cyclin K degradation with an EC50 of 0.37 nM. It also demonstrates strong inhibition of gene transcription and anti-proliferative effects in tumor cells, exhibiting significant potential in cancer research.

LL-K12-18 is a potent dual-site molecular glue that enhances CDK12-DDB1 complex formation, promoting cyclin K degradation with an EC50 of 0.37 nM. It also demonstrates strong inhibition of gene transcription and anti-proliferative effects in tumor cells, exhibiting significant potential in cancer research.