FAZ-3532 is a potent inhibitor of G3BP that binds to G3BP1 with a Kd of 0.54 μM, inhibiting co-condensation of G3BP1, Caprin1, and RNA, and blocking stress granule formation in cells. It specifically targets the protein–protein interaction within the NTF2L domain of G3BP1 without affecting its dimerization or RNA-binding, making it a useful tool to study […]

Fludarabine-Cl(ZYS-1) is an inhibitor of ADAR1 that suppresses prostate cancer growth and metastasis, potentiates antitumor immune responses, and can enhance the effect of immunotherapy.

Fludarabine-Cl(ZYS-1) is an inhibitor of ADAR1 that suppresses prostate cancer growth and metastasis, potentiates antitumor immune responses, and can enhance the effect of immunotherapy.

Fludarabine-Cl(ZYS-1) is an inhibitor of ADAR1 that suppresses prostate cancer growth and metastasis, potentiates antitumor immune responses, and can enhance the effect of immunotherapy.

Enpatoran is a potent, selective inhibitor of Toll-like receptors 7 and 8 (TLR7/8), with IC50 of 11.1 nM and 24.1 nM, respectively, in HEK293 cells. It also demonstrates potential for treating autoimmune diseases.

Enpatoran is a potent, selective inhibitor of Toll-like receptors 7 and 8 (TLR7/8), with IC50 of 11.1 nM and 24.1 nM, respectively, in HEK293 cells. It also demonstrates potential for treating autoimmune diseases.

Fludarabine-Cl(ZYS-1) is an inhibitor of ADAR1 that suppresses prostate cancer growth and metastasis, potentiates antitumor immune responses, and can enhance the effect of immunotherapy.

RS47 is a potent and specific inhibitor of the non-canonical NF-κB signaling pathway through disrupting RelB binding to its target DNA with a Kd values of 1.1 μM. It is shown to inhibit colorectal cancer (CRC) cells and B lymphoma growth, holds potential as a research tool for targeting cancers driven by hyperactive non-canonical NF-κB […]

Enpatoran is a potent, selective inhibitor of Toll-like receptors 7 and 8 (TLR7/8), with IC50 of 11.1 nM and 24.1 nM, respectively, in HEK293 cells. It also demonstrates potential for treating autoimmune diseases.

Enpatoran is a potent, selective inhibitor of Toll-like receptors 7 and 8 (TLR7/8), with IC50 of 11.1 nM and 24.1 nM, respectively, in HEK293 cells. It also demonstrates potential for treating autoimmune diseases.