REM127 is a small molecule that restores calcium homeostasis by stabilizing the septin cytoskeleton, thereby preventing pathological calcium influx in models of tauopathies. It improves synaptic plasticity, reduces tau and Aβ pathology, and rescues memory function in disease models. It exhibits a potential for treating Alzheimer’s disease and frontotemporal dementia.

REM127 is a small molecule that restores calcium homeostasis by stabilizing the septin cytoskeleton, thereby preventing pathological calcium influx in models of tauopathies. It improves synaptic plasticity, reduces tau and Aβ pathology, and rescues memory function in disease models. It exhibits a potential for treating Alzheimer’s disease and frontotemporal dementia.

REM127 is a small molecule that restores calcium homeostasis by stabilizing the septin cytoskeleton, thereby preventing pathological calcium influx in models of tauopathies. It improves synaptic plasticity, reduces tau and Aβ pathology, and rescues memory function in disease models. It exhibits a potential for treating Alzheimer’s disease and frontotemporal dementia.

FAZ-3532 is a potent inhibitor of G3BP that binds to G3BP1 with a Kd of 0.54 μM, inhibiting co-condensation of G3BP1, Caprin1, and RNA, and blocking stress granule formation in cells. It specifically targets the protein–protein interaction within the NTF2L domain of G3BP1 without affecting its dimerization or RNA-binding, making it a useful tool to study […]

REM127 is a small molecule that restores calcium homeostasis by stabilizing the septin cytoskeleton, thereby preventing pathological calcium influx in models of tauopathies. It improves synaptic plasticity, reduces tau and Aβ pathology, and rescues memory function in disease models. It exhibits a potential for treating Alzheimer’s disease and frontotemporal dementia.

FAZ-3532 is a potent inhibitor of G3BP that binds to G3BP1 with a Kd of 0.54 μM, inhibiting co-condensation of G3BP1, Caprin1, and RNA, and blocking stress granule formation in cells. It specifically targets the protein–protein interaction within the NTF2L domain of G3BP1 without affecting its dimerization or RNA-binding, making it a useful tool to study […]

FAZ-3532 is a potent inhibitor of G3BP that binds to G3BP1 with a Kd of 0.54 μM, inhibiting co-condensation of G3BP1, Caprin1, and RNA, and blocking stress granule formation in cells. It specifically targets the protein–protein interaction within the NTF2L domain of G3BP1 without affecting its dimerization or RNA-binding, making it a useful tool to study […]