Biotin-HPDP is a thiol-specific biotinylating reagent that forms a reversible disulfide bond with free cysteine residues on proteins or peptides. It is widely used to selectively tag and detect sulfhydryl groups, especially in biochemical assays. In the Biotin Switch assay, Biotin-HPDP labels newly exposed cysteine thiols after reduction of S-nitrosylated or S-sulfhydrated proteins, enabling detection […]

Biotin-HPDP is a thiol-specific biotinylating reagent that forms a reversible disulfide bond with free cysteine residues on proteins or peptides. It is widely used to selectively tag and detect sulfhydryl groups, especially in biochemical assays. In the Biotin Switch assay, Biotin-HPDP labels newly exposed cysteine thiols after reduction of S-nitrosylated or S-sulfhydrated proteins, enabling detection […]

Biotin-HPDP is a thiol-specific biotinylating reagent that forms a reversible disulfide bond with free cysteine residues on proteins or peptides. It is widely used to selectively tag and detect sulfhydryl groups, especially in biochemical assays. In the Biotin Switch assay, Biotin-HPDP labels newly exposed cysteine thiols after reduction of S-nitrosylated or S-sulfhydrated proteins, enabling detection […]

SKLB-11A is a selective, first-in-class allosteric activator of SIRT3 that binds with a Kd of 4.7 μM and enhances its deacetylase activity with EC50 of 21.95 μM. It improves cardiac function and alleviates myocardial damage in vivo.

SKLB-11A is a selective, first-in-class allosteric activator of SIRT3 that binds with a Kd of 4.7 μM and enhances its deacetylase activity with EC50 of 21.95 μM. It improves cardiac function and alleviates myocardial damage in vivo.

SKLB-11A is a selective, first-in-class allosteric activator of SIRT3 that binds with a Kd of 4.7 μM and enhances its deacetylase activity with EC50 of 21.95 μM. It improves cardiac function and alleviates myocardial damage in vivo.

CP-100356 hydrochloride is an orally active dual inhibitor of MDR1 (P-gp) and BCRP, with IC50 of ∼0.5 µM for MDR1-mediated calcein-AM transport inhibition and ∼1.5 µM for BCRP-mediated prazosin transport inhibition. It is also a weak inhibitor of OATP1B1 (IC50 ∼ 66 µM).

SKLB-11A is a selective, first-in-class allosteric activator of SIRT3 that binds with a Kd of 4.7 μM and enhances its deacetylase activity with EC50 of 21.95 μM. It improves cardiac function and alleviates myocardial damage in vivo.

CP-100356 hydrochloride is an orally active dual inhibitor of MDR1 (P-gp) and BCRP, with IC50 of ∼0.5 µM for MDR1-mediated calcein-AM transport inhibition and ∼1.5 µM for BCRP-mediated prazosin transport inhibition. It is also a weak inhibitor of OATP1B1 (IC50 ∼ 66 µM).

CP-100356 hydrochloride is an orally active dual inhibitor of MDR1 (P-gp) and BCRP, with IC50 of ∼0.5 µM for MDR1-mediated calcein-AM transport inhibition and ∼1.5 µM for BCRP-mediated prazosin transport inhibition. It is also a weak inhibitor of OATP1B1 (IC50 ∼ 66 µM).