CD1530 is a potent and selective agonist of RARγ receptor with Ki values of 150 nM. It is a potent inhibitor of heterotopic ossification (HO) and may be effective against congenital HO, with potential use in research on psoriasis, acne, photoaging, and cancer.

MDL12330A is an inhibitor of adenylyl cyclase that blocks vasopressin-induced short-circuit current (SCC). It also inhibits cAMP phosphodiesterase, which may mask its effect on adenylyl cyclase.

CD1530 is a potent and selective agonist of RARγ receptor with Ki values of 150 nM. It is a potent inhibitor of heterotopic ossification (HO) and may be effective against congenital HO, with potential use in research on psoriasis, acne, photoaging, and cancer.

CD1530 is a potent and selective agonist of RARγ receptor with Ki values of 150 nM. It is a potent inhibitor of heterotopic ossification (HO) and may be effective against congenital HO, with potential use in research on psoriasis, acne, photoaging, and cancer.

CD1530 is a potent and selective agonist of RARγ receptor with Ki values of 150 nM. It is a potent inhibitor of heterotopic ossification (HO) and may be effective against congenital HO, with potential use in research on psoriasis, acne, photoaging, and cancer.

AZD0022 is a potent, orally bioavailable, selective, reversible inhibitor of KRASG12D that drives robust pathway inhibition and anti-tumour activity in KRASG12D models.

BMS-986449 is a CELMoD molecular glue and a degrader of IKZF2/IKZF4. It redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos in Treg cells, to enhance antitumor immunity, and shows promise for advanced solid tumor research.

AMG410 is a non-covalent, selective inhibitor of pan-KRAS with IC50 of 1–4 nM for KRAS G12D, G12V, and G13D. It binds both GDP- and GTP-bound KRAS with Kd of 1 nM and 22 nM, respectively. AMG410 inhibits KRAS signaling in a nucleotide cycling-independent manner. It also suppresses proliferation in KRAS-amplified wild-type tumor cells.

BMS-986449 is a CELMoD molecular glue and a degrader of IKZF2/IKZF4. It redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos in Treg cells, to enhance antitumor immunity, and shows promise for advanced solid tumor research.

BMS-986449 is a CELMoD molecular glue and a degrader of IKZF2/IKZF4. It redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos in Treg cells, to enhance antitumor immunity, and shows promise for advanced solid tumor research.