Uric acid sodium (Monosodium urate) is a scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. It can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation and may have protective effects as an antioxidant in human diseases such […]

Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. It also inhibits H⁺, K⁺-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is selected as a drug candidate for the treatment of gastroesophageal reflux disease […]

Glycerophospholipids, cephalins are amphipathic molecules and essential components of neural membranes that are required for neural membrane structure and the proper function of integral membrane proteins, receptors, transporters, and ion channels. They also participate in apoptosis, regulate transporter and membrane-bound enzyme activities, and also serve as storage depots for lipid mediators and are useful in […]

Glycerophospholipids, cephalins are amphipathic molecules and essential components of neural membranes that are required for neural membrane structure and the proper function of integral membrane proteins, receptors, transporters, and ion channels. They also participate in apoptosis, regulate transporter and membrane-bound enzyme activities, and also serve as storage depots for lipid mediators and are useful in […]

Ponatinib hydrochloride is a potent, orally available multi-targeted inhibitor of Pan BCR-ABL kinase. It potently inhibits ABL with an IC50 of 0.37 nM, also inhibits SRC , VEGFR2, FGFR1, PDGFRα, LYN with an IC50s of 5.4 nM, 1.5 nM, 2.2 nM, 1.1 nM, 0.24 nM respectively and exhibits significant potential in cancer reserach.

Cholesteryl hemisuccinate is a cholesterol derivative and a potent inhibior of DNA polymerase and DNA topoisomerase with an IC50 of 2.9 μM, 6.3 μM, 25 μM for Rat DNA polymerase β, Human DNA polymerase λ and Human DNA topoisomerase I respectively. It exhibits anticancer effect due to its ability to inhibit DNA replication, repair and […]

Cholesteryl hemisuccinate is a cholesterol derivative and a potent inhibior of DNA polymerase and DNA topoisomerase with an IC50 of 2.9 μM, 6.3 μM, 25 μM for Rat DNA polymerase β, Human DNA polymerase λ and Human DNA topoisomerase I respectively. It exhibits anticancer effect due to its ability to inhibit DNA replication, repair and […]