N²,N²-Dimethylguanosine (m 2 2 G) is a key post-transcriptional modification found in tRNAs, where two methyl groups are added to the N² position of guanosine. This modification is essential for improving tRNA structural stability and functionality, particularly at positions like G26, which are critical for ensuring the correct conformation for efficient translation. Enzymes such as […]

BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), with MICs of of 2.3 nM and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.

Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM.

Sulfo-NHS-LC-Biotin sodium is an amine-reactive biotinylation reagent that can be used for antibody labeling.

Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC50 value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is […]

CY7-SE is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the […]

Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

DiBAC4(3) is a voltage-sensitive fluorescent dye (λex=490 nm, λem=505 nm).

2-Theoyltrifluoroacetone is a chelating agent and mitochondrial electron transfer chain inhibitor, with a IC50 value of 51.5 μM. 2-Thermoyltrifluoroacetone can chelate with various metal ions and has cytotoxicity and anti-tumor activity, which is expected to play an important role in the treatment of mitochondrial dysfunction related diseases[1][2][3].

Novobiocin (Albamycin, Cathomycin) is a potent, orally active antibiotic and an inhibitor of DNA gyrase andtopoisomerase II, and also an antagonist of heat shock protein 90 (Hsp90). It shows potential for treating β-lactam-resistant pneumococcal infections and sensitizing brain tumors to DNA cross-linking anticancer agents.