Ellipticine (NSC 71795) is a potent antitumor alkaloid that inhibits the activity of DNA topoisomerase II. It acts by intercalating into DNA, causing DNA damage and inducing cytotoxicity. It also can disrupt mitochondrial oxidative phosphorylation and exhibits potential antineoplastic effects.

BS-181 is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY-30237). BS-181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880, 3000 and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS-181 inhibits a panel of cancer cells growth (IC50=11.5 μM-37.3 μM) and induces cell apoptosis. BS-181 has […]

5-TAMRA-SE is an amine-reactive fluorescent agent, and its conjugate produces bright, pH-insensitive orange-red fluorescence with good photostability.

Insulin(cattle) is a two-chain polypeptide hormone produced by pancreatic β cells and commonly used as a growth supplement in cell culture. Its native structure is crucial for receptor interaction, regulating glucose homeostasis, while its stable hexameric form or analogs are used for storage and injection.

Pirodavir is a potent, broad-spectrum picornavirus inhibitor, and is highly active against both group A and group B rhinovirus serotypes.Pirodavir is very potent in a virus yield reduction assay (IC90=2.3 nM).

5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes.

Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

Acetyl Coenzyme A trisodium is a membrane-impermeant central metabolic intermediate involved in the TCA cycle and oxidative phosphorylation. It serves as a critical link between carbohydrate, fatty acid, and amino acid metabolism and acts as the sole acetyl group donor for protein acetylation, regulating cellular processes including autophagy via the acetyltransferase EP300.

Cefepime (BMY-28142) is a fourth-generation cephalosporin used to treat a wide range of Gram-positive and Gram-negative bacterial infections. It is approved for the management of pneumonia, urinary tract infections, skin and soft-tissue infections, intra-abdominal infections, and febrile neutropenia. Cefepime exerts its bactericidal effect by covalently binding and inhibiting penicillin-binding proteins (PBPs), thereby disrupting the final […]

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through […]