Nelfinavir (AG-1341) is a potent inhibitor of HIV protease and induces endoplasmic reticulum (ER) stress, autophagy, and apoptosis in vitro and in vivo. It also inhibits Streptolysin S (SLS) production, a key virulence factor of Streptococcus pyogenes, with IC50 of 6 µM.
More Information Supplier PageVigabatrin (γ-Vinyl-GABA) is an orally active, irreversible inhibitor of GABA transaminase, increasing brain GABA levels by blocking its breakdown. It is an antiepileptic drug that enhances inhibitory neurotransmission to control seizures and exhibits potential in treating partial seizures, infantile spasms, and Lennox-Gastaut syndrome.
More Information Supplier PageNelfinavir (AG-1341) is a potent inhibitor of HIV protease and induces endoplasmic reticulum (ER) stress, autophagy, and apoptosis in vitro and in vivo. It also inhibits Streptolysin S (SLS) production, a key virulence factor of Streptococcus pyogenes, with IC50 of 6 µM.
More Information Supplier PageVigabatrin (γ-Vinyl-GABA) is an orally active, irreversible inhibitor of GABA transaminase, increasing brain GABA levels by blocking its breakdown. It is an antiepileptic drug that enhances inhibitory neurotransmission to control seizures and exhibits potential in treating partial seizures, infantile spasms, and Lennox-Gastaut syndrome.
More Information Supplier PageVigabatrin (γ-Vinyl-GABA) is an orally active, irreversible inhibitor of GABA transaminase, increasing brain GABA levels by blocking its breakdown. It is an antiepileptic drug that enhances inhibitory neurotransmission to control seizures and exhibits potential in treating partial seizures, infantile spasms, and Lennox-Gastaut syndrome.
More Information Supplier PageVigabatrin (γ-Vinyl-GABA) is an orally active, irreversible inhibitor of GABA transaminase, increasing brain GABA levels by blocking its breakdown. It is an antiepileptic drug that enhances inhibitory neurotransmission to control seizures and exhibits potential in treating partial seizures, infantile spasms, and Lennox-Gastaut syndrome.
More Information Supplier PageZotatifin (eFT226) is a highly effective and sequence-selective inhibitor of the RNA helicase eIF4A. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5′-UTRs, with an IC50 of 2 nM, and disrupts the assembly of the eIF4F initiation complex. By enhancing the interaction between eIF4A and polypurine RNA sequence or structural […]
More Information Supplier PageGiredestrant (GDC-9545; RG6171) is an efficient and potent selective estrogen receptor degrader and a full antagonist with an IC50 of 0.05 nM in T-47D wild-type cells. It also exhibits anti-proliferative activity.
More Information Supplier Page“SD-36 is a potent, selective and efficacious PROTAC degrader of STAT3 protein with Kd of ~50 nM. It also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 with IC50 of 10 nM. It also exerts anti-tumor activity. SD-36 is a potent, selective and efficacious PROTAC degrader of STAT3 protein […]
More Information Supplier PageMilademetan(RAIN-32, DS-3032) is an oral, selective inhibitor of the MDM2-p53 complex that reactivates p53 to induce cancer cell apoptosis and exhibits an anti-tumor effect.
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