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Donepezil HCL Intermediates 2 inquiry  | Purity Not Available

Protheragen-ING

Desbenzyl Donepezil Hydrochloride is an impurity of Donepezil, which is a centrally acting reversible acetyl cholinesterase inhibitor for the treatment of moderate to severe Alzheimer’s disease.

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Donepezil HCL Intermediates 1 inquiry  | Purity Not Available

Protheragen-ING

5,6-Dimethoxy-2-(4-pyridylmethylene)-1-indanone is one of Donepezil impurities. Donepezil, a highly specific reversible acetylcholinesterase (AChE) inhibitor, is used to treat moderate to severe Alzheimer’s disease.

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Pemetrexed inquiry  | Purity Not Available

Protheragen-ING

Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2′-deoxyuridine-5′-monophosphate (dUMP) to 2′-deoxythymidine-5′-monophosphate (dTMP), an essential precursor in DNA synthesis.

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Peimei p-Toluenesulfonic Acid inquiry  | Purity Not Available

Protheragen-ING

An impurity of Pemetrexed, which has been approved by FDA in 2004 for the treatment of malignant pleural mesothelioma (MPM) in combination with cisplatin, a platinum-containing chemotherapeutic drug.

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Pemetrexed Diethyl Ester inquiry  | Purity Not Available

Protheragen-ING

Pemetrexed diethyl ester is one of pemetrexed intermediates. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2′-deoxyuridine-5′-monophosphate (dUMP) to 2′-deoxythymidine-5′-monophosphate (dTMP), an essential precursor in DNA synthesis.

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Bicalutamide Intermediate (epoxy) inquiry  | Purity Not Available

Protheragen-ING

Bicalutamide Epoxide Impurity is an intermediate in synthesis of more complex pharmaceutical compounds. It is used in the synthesis of potential impurities of Bicalutamide.

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