Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase.

(S)-b-aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine.

Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM.

Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B.

Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity.

Falcarindiol is a cytotoxic and anti-inflammatory polyacetylenic oxylipin found in food plants of the Apiaceae family, such as carrots. It functions as a partial agonist of peroxisome proliferator-activated receptor γ (PPARγ) with an EC50 of 3.29 µM in a luciferase reporter assay, leading to the upregulation of the cholesterol transporter ABCA1 in cells. It also promotes […]

Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity. Ezetimibe is a potent cholesterol absorption inhibitor.

Methotrexate metabolite (DAMPA) is an active metabolite of Methotrexate. Methotrexate is a Folic acid (HY-16637) antagonist, widely used as an immunosuppressant. Methotrexate metabolite is an antimalarial agent that inhibits parasite growth under physiological folic acid conditions, with IC50 values of 446 nM and 812 nM against folic acid-sensitive strains and highly resistant strains, respectively. Methotrexate […]

Salcaprozate sodium (SNAC) is an oral absorption promoter, with potential as a delivery agent for oral forms of heparin and insulin. It is intestinal permeation enhancer (PE) that increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation. It can be used in manufacturing uncoated oral tablet, by […]

5-Hydroxypyrazine-2-Carboxylic Acid, a metabolite of anti-tuberculosis drug pyrazinamide (PZA).