Ceftobiprole (Ro 63-9141) is a broad-spectrum cephalosporin with high levels of in vitro activity against methicillin- (MRSA) and vancomycin-resistant staphylococci (VRSA) and penicillin-resistant streptococci with a MIC90 value of 2 μg/mL for MRSA. Ceftobiprole also inhibits gram-positive and gram-negative pathogens.

Acridine Orange 10-Nonyl Bromide (Nonylacridine orange) is a mitochondrial-specific fluorescent probe with an absorption wavelength of 489 nm and an emission wavelength of 525 nm, commonly used in flow cytometry to study mitochondrial properties. It’s binding is unaffected by uncouplers, ionophores, or nucleases, making it a stable and reliable tool for cellular research.

Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity.

Reparixin L-lysine salt is an allosteric inhibitor of chemokine receptor 1/2 (CXCR1/2) activation.

MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC50 and an EC50 value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity.

Ch55 is a synthetic analog of retinoic acid that acts as a potent agonist of RAR, binding with high affinity to retinoic acid receptors RAR-α, RAR-β, and RAR-γ, while showing no binding to cellular retinoic acid binding protein (CRABP). It demonstrates anti-fibrotic effects in preclinical models, reducing collagen deposition and hypertrophy in dermal tissues.

Halofantrine hydrochloride (SKF-102886) is a blocker of delayed rectifier potassium current via the inhibition of human-ether-a-go-go-related gene (HERG) channel and a potent antimalarial compound.

LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM.

PZM21 is a potent and selective μ opioid receptor agonist with an EC50 of 1.8 nM.

PSI-7409 is the active 5′-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV.