Isoflavone reductases (IFRs), like birch pollen allergen Bet v 6.0102, have also been found in apple, pear, orange, mango, lychee and other plants. They are plant defense proteins and appear to be induced by plant stress, e.g. high salinity, freeze or drought.

Bet v 4.0101 is primarily expressed in mature birch (Betula verrucosa) pollen. It is a 9 kDa calcium-binding protein of 2-EF-hand type, which is represented in pollen of a wide range of plant species. This extensive cross-reactivity can serve as a marker allergen for plant polysensitization.

Like all profilins, minor grass pollen allergen Phl p 12.0101 is involved in cytoskeleton dynamics by binding to actin. Immunological cross-reactivity regarding IgE binding, among pollen profilins and profilins of plant-derived foods, is well known.

Milk is one of the first food components introduced into the diet and therefore represents one of the most important food allergen sources in terms of frequency and severity of allergic manifestations. The symptoms of cow’s milk allergy are due to IgE-mediated activation of mast cells and basophils as well as to activation of allergen-specific […]

Milk is one of the first food components introduced into the diet and therefore represents one of the most important food allergen sources in terms of frequency and severity of allergic manifestations. The symptoms of cow’s milk allergy are due to IgE-mediated activation of mast cells and basophils as well as to activation of allergen-specific […]

Milk is one of the first food components introduced into the diet and therefore represents one of the most important food allergen sources in terms of frequency and severity of allergic manifestations. The symptoms of cow’s milk allergy are due to IgE-mediated activation of mast cells and basophils as well as to activation of allergen-specific […]

IgE-mediated hypersensitive reactions to ingestion of shellfish are among the most serious forms of food allergies.Cha f 1 is a 34-kd recombinant protein reactive to the IgE antibodies from patients with crab allergies.

Tri a 14.0101, a non-specific lipid transfer protein (nsLTP), is a major wheat (Triticum aestivum) allergen. Sensitization to this allergen is associated with baker’s asthma, a frequent occupational allergic disease caused mainly by inhalation of cereal flour, particularly wheat flour. The protein involves four helical fragments and irregular and stable C-terminal regions which are highly […]

Seed storage proteins have been identified as major allergens in several other tree nuts and peanut. 2S albumin Cor a 14.0101 is an abundant seed storage protein in hazelnut. Sensitization to Cor a 14.0101 has been shown to be a risk marker for severe allergic reactions, especially in children.

Sensitization to Cor a 9, an 11S legumin-like seed storage globulin and a major allergen from Corylus avellana, indicates primary hazelnut allergy. The protein has been reported to be associated with severe systemic reactions.