KDM5-IN-1 is a potent, selective and orally bioavailable inhibitor of KDM5 with an IC50 value of 15.1 nM. It displays an increased cell potency with an EC50 value of 0.34 μM, respectively.

TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses.

CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.IC50 value: 63 nMTarget: CaMKII

Guluronic acid (G2013), one of the organic building blocks of hyaluronic acid, is a nonsteroidal anti-inflammatory agent has favorable anti-inflammatory effect.

ON-013100 is a benzylstyrylsulfone antineoplastic agent and a potent mitotic inhibitor. It inhibits CDK4 and cyclin D1 expression while suppressing MDM2 and reducing p53 levels, disrupting mitogenic signaling and enhancing its anticancer activity.

RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide (RAP) possesses anti-tumor and anti-inflammatory activities.

TTA-A2 is a potent and selective antagonist of T-type calcium channel with an IC50 of 9.4 nM, and reduced PXR activation, promoting slow-wave sleep in mice. It shows strong efficacy in rodent models of epilepsy and sleep, making it a valuable preclinical tool for the research of a variety of human neurological diseases.

BODIPY505/515 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY […]

MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor with an IC50 of 2 nM.

INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 specifically blocks targeting of NFAT(P) substrate to the  calcineurin (CN) phosphatase site and is an effective inhibitor of CN-NFAT signaling.