L-Leucyl-L-Leucine methyl ester hydrobromide (Leu-Leu-ome hydrobromide) is a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates cytotoxic lymphocytes, including natural killer (NK) cells, from mixed lymphocyte populations. It also induces stress in the endolysosomal pathway, highlighting its potential impact on immune cell regulation.

L-Asparaginase(L-ASNase) is a deamidating enzyme that hydrolyzes L-asparagine and L-glutamine, depleting L-asparagine in the blood and bone marrow. It exhibits anti-leukemic effects by inhibiting RNA and DNA synthesis, leading to blastic cell apoptosis, and is used in acute lymphoblastic leukemia (ALL) research and treatment.

Rat CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) and a highly selective antagonist of CGRP receptor. It exhibits anti-nociceptive effects and is effective in abolishing mechanical and thermal allodynia produced by spinal hemisection and may play a role in chronic central neuropathic pain.

A 438079 is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

Ro 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and […]

DMG-PEG 2000 is used?for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the?lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.

Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist. Firategrast reduces trafficking of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity.

FAPI-4 is a potent fibroblast activation protein (FAP) inhibitor for the targeting FAP. FAPI-4 can be used in cancer research. 68Ga-FAPI-4 PET/CT is a promising new diagnostic method for imaging various kinds of cancer, with good tumor-to-background contrast ratios.

Zosuquidar (LY335979) is a P-glycoprotein (P-gp) inhibitor (Ki=59 nM). Zosuquidar shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research.

The 5-Ph-IAA is a bumped-IAA analogue, that establishes the auxin-inducible degron 2 (AID2) system with the OsTIR1(F74G) mutant, enabling precise, rapid degradation with 670-fold lower ligand concentration. It induces rapid and efficient depletion of mAID-fused proteins to study protein function in living cells, exhibiting significant tumor suppression properties.