Aldoxorubicin, also known as INNO-206 and Doxo-EMCH, is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin with antineoplastic activity. INNO-206 binds selectively to the cysteine-34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and, […]

Aldoxorubicin, also known as INNO-206 and Doxo-EMCH, is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin with antineoplastic activity. INNO-206 binds selectively to the cysteine-34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and, […]

Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of the approved drug belantamab mafodotin in multiple myeloma and some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates, the name mafodotin refers to MMAF plus its attachment structure to the antibody.

The pyrrolobenzodiazepines (PBDs) are a class of antitumor antibiotics. PBDs are sequence-selective DNA minor-groove binding crosslinking agents originally discovered in Streptomyces species and are significantly more potent than systemic chemotherapeutic drugs. Pyrrolobenzodiazepines are potent inhibitors of nucleic acid synthesis because of their ability to recognize and bind to specific sequences of DNA and form a […]

The pyrrolobenzodiazepines (PBDs) are a class of antitumor antibiotics. PBDs are sequence-selective DNA minor-groove binding crosslinking agents originally discovered in Streptomyces species and are significantly more potent than systemic chemotherapeutic drugs. Pyrrolobenzodiazepines are potent inhibitors of nucleic acid synthesis because of their ability to recognize and bind to specific sequences of DNA and form a […]

A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. n-acetylneuraminic acid, NANA) linked on the sugar chain.Recently, gangliosides have been found to be highly important molecules in immunology. Natural and semisynthetic gangliosides are considered possible therapeutics for neurodegenerative disorders.

A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. n-acetylneuraminic acid, NANA) linked on the sugar chain.Ganglioside GT1b (d18:1/26:1(17Z)) is a GT1b ganglioside, A glycosphingolipid (ceramide and oligosaccharide) or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. It […]

A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. n-acetylneuraminic acid, NANA) linked on the sugar chain.Ganglioside GT1b (d18:1/26:1(17Z)) is a GT1b ganglioside, A glycosphingolipid (ceramide and oligosaccharide) or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. It […]

MMAD is a tubulin inhibitor and used to produce site-specific antibody drug conjugates.

MMAD is a tubulin inhibitor and used to produce site-specific antibody drug conjugates.