Vitronectin (VTN) is a glycoprotein that is involved in cell adhesion, migration, and survival. It is a multifunctional protein that plays a role in processes such as blood coagulation, wound healing, and tissue regeneration. VTN also has potential therapeutic applications for diseases such as cancer and cardiovascular disease.

Dickkopf related protein 1 (Dkk-1) is the founding member of the Dickkopf family of proteins that includes Dkk-1, -2, -3, -4, and a related protein. Dkk antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an […]

Heparin-binding epidermal growth factor (HB-EGF)-like growth factor (EGF) is found in cerebral neurons. Human HB-EGF- shares 76% and 73% aa sequence identity with rat and mouse HB-EGF. Its expression is increased after hypoxic or ischemic injury, which also stimulates neurogenesis. HB-EGF has been implicated as a participant in a variety of normal physiological processes such […]

Wnt-3a belongs to the Wnt family of signaling proteins, which plays an important role in maintaining the integrity of embryonic and adult tissues.The Wnt family is highly conserved and cysteine-rich.The Wnt signaling pathway can be divided into classical and non-classical pathways, and is involved in the β-catenin-mediated classical signaling pathway, including Wnt1, Wnt2, Wnt2b, Wnt3, […]

Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-α receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, […]

Human HB-EGF (Heparin-Binding EGF-like growth factor), also known as the DTR (diphtheria toxin receptor), is a 12-16 kDa member of the EGF family of peptide growth factors. It is further classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Mature HB-EGF is a soluble peptide […]

Epidermal Growth Factor (EGF) is a small growth factor containing 53 amino acid residues capable of stimulating the proliferation of both mesenchymal and epithelial cells. The mature protein is much smaller, only 53 aa, and is generated by proteolytic cleavage of the EGF domain proximal to the transmembrane region. EGF is well conserved across mammals […]

Heparin-binding epidermal growth factor (HB-EGF)-like growth factor (EGF) is found in cerebral neurons. Human HB-EGF- shares 76% and 73% aa sequence identity with rat and mouse HB-EGF. Its expression is increased after hypoxic or ischemic injury, which also stimulates neurogenesis. HB-EGF has been implicated as a participant in a variety of normal physiological processes such […]

Epidermal growth factor (EGF) is a small, potent growth factor capable of inducing cell proliferation, differentiation, and survival. EGF is the founding member of the EGF family that also includes TGF-alpha, amphiregulin (AR), betacellulin (BTC), epiregulin (EPR), heparin_x005f_x005f_x001E_binding EGFlike growth factor (HBEGF), epigen, and the neuregulins (NRG)-1 through -6. Members of The EGF family are […]

Human epidermal growth factor (EGF) protein is a naturally occurring protein that plays a vital role in cell growth and development. It is produced and released by various cells in the body, including the skin, salivary glands, and kidneys. human EGF protein is a vital protein in the body that plays a crucial role in […]