Compound E (γ-Secretase-IN-1) is a potent inhibitor of γ-secretase, which blocks γ-secretase-mediated cleavage of Notch with an IC50 of 0.32 nM. It also suppresses the production of β-amyloid(40) and β-amyloid(42) with IC50 values of 0.24 nM and 0.37 nM, respectively. It also inhibits Notch signalling, significantly disrupting gonadotropin-dependent follicle growth and halting progression to the […]

Cytochrome c is a mitochondrial protein essential for electron transport and energy production. Upon apoptotic signals, it binds cardiolipin, gains peroxidase activity, and triggers cell death via caspase activation. Its function is tightly regulated by tissue-specific phosphorylation and ATP binding, which control respiration, ROS production, and apoptosis sensitivity.

Nangibotide TFA is a synthetic peptide that specifically inhibits the TREM‐1 (triggering receptor expressed on myeloid cells‐1) pathway by acting as a decoy receptor to block its activation. It reduces excessive inflammation, restores vascular function, and improves survival in animal models of septic shock.

Cytochrome c is a mitochondrial protein essential for electron transport and energy production. Upon apoptotic signals, it binds cardiolipin, gains peroxidase activity, and triggers cell death via caspase activation. Its function is tightly regulated by tissue-specific phosphorylation and ATP binding, which control respiration, ROS production, and apoptosis sensitivity.

Nangibotide TFA is a synthetic peptide that specifically inhibits the TREM‐1 (triggering receptor expressed on myeloid cells‐1) pathway by acting as a decoy receptor to block its activation. It reduces excessive inflammation, restores vascular function, and improves survival in animal models of septic shock.

Nangibotide TFA is a synthetic peptide that specifically inhibits the TREM‐1 (triggering receptor expressed on myeloid cells‐1) pathway by acting as a decoy receptor to block its activation. It reduces excessive inflammation, restores vascular function, and improves survival in animal models of septic shock.

Nangibotide TFA is a synthetic peptide that specifically inhibits the TREM‐1 (triggering receptor expressed on myeloid cells‐1) pathway by acting as a decoy receptor to block its activation. It reduces excessive inflammation, restores vascular function, and improves survival in animal models of septic shock.

Jagged-1 (188-204) (TFA) is a peptide fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 also induces the maturation of monocyte-derived human dendritic cells.

Jagged-1 (188-204) (TFA) is a peptide fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 also induces the maturation of monocyte-derived human dendritic cells.

Jagged-1 (188-204) (TFA) is a peptide fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 also induces the maturation of monocyte-derived human dendritic cells.