Pralatrexate 10mM/1mL | Purity Not Available
Selleck Chemicals
Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis.
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NVP-BEP800 50mg | Purity Not Available
Selleck Chemicals
NVP-BEP800 (VER82576) is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM, exhibits>70-fold selectivity against Hsp90 family members Grp94 and Trap-1.
More Information Supplier PageHMN-214 5mg | Purity Not Available
Selleck Chemicals
HMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.
More Information Supplier PageAEE788 (NVP-AEE788) 5mg | Purity Not Available
Selleck Chemicals
AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.
More Information Supplier PagePHA-793887 50mg | Purity Not Available
Selleck Chemicals
PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM. It is greater than 6-fold more selective for CDK2, 5, and 7 than CDK1, 4, and 9. PHA-793887 induces cell-cycle arrest and apoptosis. Phase 1.
More Information Supplier PagePIK-93 25mg | Purity Not Available
Selleck Chemicals
PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.
More Information Supplier PagePonatinib 10mg | Purity Not Available
Selleck Chemicals
Ponatinib is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.
More Information Supplier PageLomibuvir (VX-222) 5mg | Purity Not Available
Selleck Chemicals
Lomibuvir (VX-222, VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. Phase 2.
More Information Supplier PageZosuquidar 3HCl 5mg | Purity Not Available
Selleck Chemicals
Zosuquidar 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.
More Information Supplier PageZosuquidar 3HCl 50mg | Purity Not Available
Selleck Chemicals
Zosuquidar 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.
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