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AZD2461 25mg  | Purity Not Available

Selleck Chemicals

AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.

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XL019 25mg  | Purity Not Available

Selleck Chemicals

XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, exhibiting >50-fold selectivity over JAK1, JAK3 and TYK2. Phase 1.

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Wnt-C59 (C59) 5mg  | Purity Not Available

Selleck Chemicals

Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells.

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AZD3514 50mg  | Purity Not Available

Selleck Chemicals

AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.

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LCL161 25mg  | Purity Not Available

Selleck Chemicals

LCL-161, a small molecule second mitochondrial activator of caspase (SMAC) mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).

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LCL161 5mg  | Purity Not Available

Selleck Chemicals

LCL-161, a small molecule second mitochondrial activator of caspase (SMAC) mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).

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PP2 10mM/1mL  | Purity Not Available

Selleck Chemicals

PP2 (AG 1879, AGL 1879), a Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM in cell-free assays, ~100-fold less potent to EGFR, inactive for ZAP-70, JAK2 and PKA.

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PP2 5mg  | Purity Not Available

Selleck Chemicals

PP2 (AG 1879, AGL 1879), a Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM in cell-free assays, ~100-fold less potent to EGFR, inactive for ZAP-70, JAK2 and PKA.

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Binimetinib (MEK162) 50mg  | Purity Not Available

Selleck Chemicals

Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy. Phase 3.

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Binimetinib (MEK162) 10mg  | Purity Not Available

Selleck Chemicals

Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy. Phase 3.

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