Oprozomib 10mM/1mL | Purity Not Available
Selleck Chemicals
Oprozomib is an orally bioavailable inhibitor for CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. Phase 1/2.
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Embelin 50mg | Purity Not Available
Selleck Chemicals
Embelin (Embelic Acid, NSC 91874), a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay.
More Information Supplier PageBIX 01294 10mM/1mL | Purity Not Available
Selleck Chemicals
BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3.
More Information Supplier PageAZD2461 25mg | Purity Not Available
Selleck Chemicals
AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.
More Information Supplier PageXL019 25mg | Purity Not Available
Selleck Chemicals
XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, exhibiting >50-fold selectivity over JAK1, JAK3 and TYK2. Phase 1.
More Information Supplier PageWnt-C59 (C59) 5mg | Purity Not Available
Selleck Chemicals
Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells.
More Information Supplier PageAZD3514 50mg | Purity Not Available
Selleck Chemicals
AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.
More Information Supplier PageLCL161 25mg | Purity Not Available
Selleck Chemicals
LCL-161, a small molecule second mitochondrial activator of caspase (SMAC) mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).
More Information Supplier PageLCL161 5mg | Purity Not Available
Selleck Chemicals
LCL-161, a small molecule second mitochondrial activator of caspase (SMAC) mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).
More Information Supplier PagePP2 10mM/1mL | Purity Not Available
Selleck Chemicals
PP2 (AG 1879, AGL 1879), a Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM in cell-free assays, ~100-fold less potent to EGFR, inactive for ZAP-70, JAK2 and PKA.
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