EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM in a cell-free assay and demonstrates >1,200-fold selectivity for DOT1L over all other tested PMTs. EPZ004777 induces apoptosis.
More Information Supplier PageARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
More Information Supplier PageARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
More Information Supplier PagePF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
More Information Supplier PagePoziotinib is an irreversible pan-HER inhibitor with IC50 of 3.2 nM, 5.3 nM and 23.5 nM for HER1, HER2, and HER4, respectively. Poziotinib also induces apoptosis and G1 cell cycle arrest. Phase 2.
More Information Supplier PageTasisulam (LY573636) is an antitumor agent and an apoptosis inducer via the intrinsic pathway. Phase 3.
More Information Supplier PageID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.
More Information Supplier PageIOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2.
More Information Supplier Page6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C).
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