Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
More Information Supplier PageNutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.
More Information Supplier PageNutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.
More Information Supplier PageNVP-TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.
More Information Supplier PageNVP-BAG956 acts as a potent, reversible, and ATP-competitive PI 3-K/PDK1 dual kinase inhibitor, displaying much reduced potency against VEGFR1 (IC50 = 2.56 uM) and little or no activity toward a panel of 15 other kinases (IC50 >10 uM).
More Information Supplier PageOrg 27569 is a potent CB1 receptor allosteric modulator (pEC50 = 8.24).
More Information Supplier PageOrg 27569 is a potent CB1 receptor allosteric modulator (pEC50 = 8.24).
More Information Supplier PageOrg 27569 is a potent CB1 receptor allosteric modulator (pEC50 = 8.24).
More Information Supplier PageOrg 27569 is a potent CB1 receptor allosteric modulator (pEC50 = 8.24).
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