Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.
More Information Supplier PageTAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. Phase 2.
More Information Supplier PagePifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR).
More Information Supplier PageCarbazochrome sodium sulfonate (AC-17) is an antihemorrhagic for use in the treatment of hemorrhoids.
More Information Supplier PageClevudine(Levovir,L-FMAU) is an antiviral drug for the treatment of hepatitis B.
More Information Supplier PageClevudine(Levovir,L-FMAU) is an antiviral drug for the treatment of hepatitis B.
More Information Supplier PageRivaroxaban is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM in cell-free assays, respectively. It is selective for human factor Xa, for which it has >10 000-fold greater selectivity than for other biologically relevant serine proteases (IC50 >20 μM).
More Information Supplier PageRivaroxaban is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM in cell-free assays, respectively. It is selective for human factor Xa, for which it has >10 000-fold greater selectivity than for other biologically relevant serine proteases (IC50 >20 μM).
More Information Supplier PageParoxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.
More Information Supplier PageParoxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.
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