AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 ??M, 0.48 ??M and 0.18 ??M; does not inhibit BIR3 domain and BID
More Information Supplier PageGSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.
More Information Supplier PageGSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.
More Information Supplier PageGSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.
More Information Supplier PageGSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.
More Information Supplier PageGSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.
More Information Supplier PageGLYX-13 is a selective weak partial agonist of the glycine site of the NMDA receptor (IA ?? 25%) which is under development by Naurex as an adjunctive therapy for treatment-resistant depression.
More Information Supplier PageGLYX-13 is a selective weak partial agonist of the glycine site of the NMDA receptor (IA ?? 25%) which is under development by Naurex as an adjunctive therapy for treatment-resistant depression.
More Information Supplier PageML-314 is a brain penetrant nonpeptidic ??-arrestin biased ggonist of the neurotensin NTR1 receptor, which exhibits full agonist behavior against NTR1 (EC50 = 2.0 ??M) in the primary assay and selectivity against NTR2.
More Information Supplier PageML-314 is a brain penetrant nonpeptidic ??-arrestin biased ggonist of the neurotensin NTR1 receptor, which exhibits full agonist behavior against NTR1 (EC50 = 2.0 ??M) in the primary assay and selectivity against NTR2.
More Information Supplier Page
