Anticancer compound. NF-kappaB inhibitor. Apoptosis inducer. Potent anti-inflammatory agent. Telomerase inhibitor. Anti-trypanosomal and antiprotozoal compound Antibiotic. Shows anti-proliferative effects in 3T3-L1 preadipocytes. Autophagy inducer.
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Selective inhibitor of 5-lipoxygenase. Apoptosis and cell cycle arrest inducer. Anticancer compound. Inhibits ERK1/2, JNK, and NF-kappaB activation and expression of Raf-1 and Ras. Anti-proliferative compound. Anti-inflammatory and immunosuppressive. Anti-apoptotic compound in hepatocytes. Antioxidant. Antidiabetic. Enhances hepatic and plasma glucose metabolism and increases insulin secretion in type 2 diabetic mice. Inhibits angiogenesis by blocking STAT3 […]
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Immunosuppressant. Calcineurin inhibitor with lower activity than Cyclosporin A (AG-CN2-0079). Antifungal. Antitumor.
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Immunosuppressant. Calcineurin inhibitor with lower activity than Cyclosporin A (AG-CN2-0079). Antifungal. Antitumor.
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Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Human dCTP pyrophosphatase 1 inhibitor. Interferes […]
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Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Human dCTP pyrophosphatase 1 inhibitor. Interferes […]
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Potent inhibitor of tumor promoting phorbol ester TPA/PMA (AG-CN2-0010) effects in vivo. Antifungal. Potent and effective inhibitor of formyl peptide receptor (FPR) and formyl peptide-induced superoxide formation. Shows no immunosuppresive activity like other cyclosporins.
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Potent inhibitor of tumor promoting phorbol ester TPA/PMA (AG-CN2-0010) effects in vivo. Antifungal. Potent and effective inhibitor of formyl peptide receptor (FPR) and formyl peptide-induced superoxide formation. Shows no immunosuppresive activity like other cyclosporins.
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Immunosuppressant. Anticancer compound. Chemotherapeutic agent. Depolymerizes microtubules and irreversibly blocks binding of tubulin to microtubule proteins. Apoptosis inducer and cell cycle inhibitor in G2/M phase. Autophagy inhibitor. Inhibits microtubule-mediated fusion of autophagosome with lysosme. Inducer of IL-1beta production. Activates alone and synergistically together with doxorubicin the NLRP3-inflammasome mediated processing of IL-1beta. Monoamine oxidase (MAO) inhibitor.
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Immunosuppressant. Anticancer compound. Chemotherapeutic agent. Depolymerizes microtubules and irreversibly blocks binding of tubulin to microtubule proteins. Apoptosis inducer and cell cycle inhibitor in G2/M phase. Autophagy inhibitor. Inhibits microtubule-mediated fusion of autophagosome with lysosme. Inducer of IL-1beta production. Activates alone and synergistically together with doxorubicin the NLRP3-inflammasome mediated processing of IL-1beta. Monoamine oxidase (MAO) inhibitor.
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