Anti-malaria. Apoptosis inducer. Anti-cancer. Inhibits production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide (NO).
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Purine alkaloid related to caffeine. Potent antioxidant. Not through direct scavenging of ROS but strengthen antioxidant systems in vivo. Anti-inflammatory and antinociceptive compound. Suggested to have adenosine receptor agonistic activity and also acting on dopamine receptors. Shown to have potent sedative and hypnotic properties. Ameliorated learning and memory impairments caused by central fatigue. Shown to […]
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Purine alkaloid related to caffeine. Potent antioxidant. Not through direct scavenging of ROS but strengthen antioxidant systems in vivo. Anti-inflammatory and antinociceptive compound. Suggested to have adenosine receptor agonistic activity and also acting on dopamine receptors. Shown to have potent sedative and hypnotic properties. Ameliorated learning and memory impairments caused by central fatigue. Shown to […]
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Anticancer and antiangiogenic compound. Induces apoptosis, cell cycle arrest and autophagy in various cancer cell lines. At low concentrations acts as antioxidant reducing oxidative stress generated through the TCR signaling pathway. At high concentration induces O2- and causes oxidative-stress-mediated apoptosis. Potent anti-inflammatory and anti-atherosclerotic agent. NF-kappaB inhibitor by directly targeting IkappaB kinase. Inhibits STAT-mediated anti-apoptotic […]
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Selective Ca2+-calmodulin dependent cGMP-phosphodiesterase (PDE1) inhibitor. Shows vasorelaxant activity. Neuroprotective agent. Selectively inhibits voltage-sensitive 2+ channels Potent anti-inflammatory agent. Inhibitor of NF-kappaB-dependent inflammatory responses by directly targeting IKK. Shown to inhibit the NLRP3 inflammasome. Antioxidant. Free radical scavenger. Anticancer compound. Anticonvulsant.
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Selective Ca2+-calmodulin dependent cGMP-phosphodiesterase (PDE1) inhibitor. Shows vasorelaxant activity. Neuroprotective agent. Selectively inhibits voltage-sensitive 2+ channels Potent anti-inflammatory agent. Inhibitor of NF-kappaB-dependent inflammatory responses by directly targeting IKK. Shown to inhibit the NLRP3 inflammasome. Antioxidant. Free radical scavenger. Anticancer compound. Anticonvulsant.
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Mycotoxin. Alkaloid antibiotic. Bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor. Antineoplastic activity. Moderate cytotoxicity against A-549 and HL-60 cell lines. Induces cell cycle arrest through G2/M phase, presumably by inhibiting tubulin polymerization. Antifouling agent against the barnacle Balanus amphitrite.
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One of the principal active constituents of St. John’s Wort (Hypericum perforatum). Hypericin is a photosensitive pigment/chromophore with bright red fluorescence emission (lambdamax: 594nm). Has a high triplet quantum yield and ability to produce considerable amounts of singlet oxygen and other ROS species when photoactivated. Antiviral, anticancer and antidepressant agent. Inactivates enveloped viruses (including HIV). […]
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One of the principal active constituents of St. John’s Wort (Hypericum perforatum). Hypericin is a photosensitive pigment/chromophore with bright red fluorescence emission (lambdamax: 594nm). Has a high triplet quantum yield and ability to produce considerable amounts of singlet oxygen and other ROS species when photoactivated. Antiviral, anticancer and antidepressant agent. Inactivates enveloped viruses (including HIV). […]
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