AdipoGen Life Sciences
Highly potent Na+/K+-ATPase inhibitor, blocking the active efflux of Na+ and reuptake of K+. Water soluble cardiotonic glycoside from the class of bufadienolides (with 2-pyrone ring). Inhibits cancer cell growth in vitro. Shown to induce caspase-dependent apoptosis, reducing MDR resistance and the rate of mitochondrial oxidative phosphorylation in cancer cells. Inotropic by increasing the intracellular […]
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AdipoGen Life Sciences
Potent actin depolymerization inhibitor. Shown to have a different mechanism of action compared to jasplakinolide (Prod. No. AG-CN2-0037), binding to a different site. Binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, stabilizing F-actin without affecting actin polymerization or nucleation. Does not bind to monomeric actin (G-actin). Immunomodulator with anti-inflammatory and […]
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AdipoGen Life Sciences
Potent actin depolymerization inhibitor. Shown to have a different mechanism of action compared to jasplakinolide (Prod. No. AG-CN2-0037), binding to a different site. Binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, stabilizing F-actin without affecting actin polymerization or nucleation. Does not bind to monomeric actin (G-actin). Immunomodulator with anti-inflammatory and […]
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Convulxin
50 µg
| Purity Not Available
AdipoGen Life Sciences
Glycoprotein GPVI receptor agonist. Can be used for studies on platelet receptors. Activates mammalian platelets via binding and clustering of GPVI-receptors under physiological conditions. Occupation and clustering of GPVI activates Src family kinases, phosphorylates Fc receptor gamma-chain and activates p72SYK that is critical for downstream activation of platelets. Causes cardiovascular and respiratory disturbances. Prostaglandins are […]
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AdipoGen Life Sciences
Antidiabetic agent. Potent and selective partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor regulating lipid and glucose metabolism. Has low nanomolar binding affinity to PPARgamma and micromolar binding to the isotypes PPARalpha and PPARbeta/delta. The binding affinity constant to PPARgamma is 12 times lower than Amorfrutin A (Prod. No. AG-CN2-0462). Glucose-lowering agent. […]
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AdipoGen Life Sciences
Potent anticancer compound. Cell permeable potent DNA topoisomerase I (Topo I) complex inhibitor. Potent apoptosis inducer. Binds reversibly to the DNA topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, […]
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AdipoGen Life Sciences
Potent anticancer compound. Cell permeable potent DNA topoisomerase I (Topo I) complex inhibitor. Potent apoptosis inducer. Binds reversibly to the DNA topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, […]
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AdipoGen Life Sciences
Antidiabetic agent. Potent and selective partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor regulating lipid and glucose metabolism. Has nanomolar binding affinity to PPARgamma and micromolar binding to the isotypes PPARalpha and PPARbeta/delta. Glucose-lowering agent. Improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity. Shows […]
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AdipoGen Life Sciences
Chirality inducing agent. Useful tool as resolving agent to separate the isomers and purify racemic mixtures (e.g. DL-lysine) by fractionally crystallizing the product to obtain the pure isomer (e.g. L-lysine). Can also be used as building block. Insect repellent. Stimulator of osteoblast differentiation.
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AdipoGen Life Sciences
Anti-obesity agent. Potent leptin sensitizer. Antioxidant. Potent lipid peroxidation inhibitor. NADPH oxidases (NOX1, 2, 4 and 5) inhibitor. Anti-inflammatory. NF-kappaB inhibitor. HSP90 inhibitor and HSP70 inducer. Anticancer agent. Apoptosis and autophagy inducer. Inhibits PI3K/Akt signaling pathways. Anti-metastatic and anti-angiogenic compound. Reduces VEGFR expression and inhibits HIF-1alpha pathway. Topoisomerase II inhibitor. 20S proteasome chymotrypsin-like activity inhibitor. […]
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