Cell permeable gamma-secretase inhibitor (IC50 = 115 nM for total beta-amyloid, IC50 = 200 nM for beta-amyloid 1-42). Reduces Abeta levels in vivo. Blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD). Does not inhibit persenilinase. Notch processing inhibitor. Enhances neuronal differentiation independent of sonic hedgehog (Shh) signaling. CDK5 activity inhibitor. Apoptosis […]
More Information Supplier PageSelective 5-HT2A serotonin receptor antagonist. ATP-sensitive potassium channel inhibitor. hERG potassium channel blocker.
More Information Supplier PageMicrotubule inhibitor. Antitumor compound. Mitosis inhibitor. Arrests the cell cycle at G2/M phase. Promotes tubulin depolymerization. Induces fragmentation of the Golgi complex. Inhibits the T cell antigen receptor. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway. Apoptosis inducer. Autophagy inhibition through prevention of autophagosome-lysosome fusion.
More Information Supplier PageMicrotubule inhibitor. Antitumor compound. Mitosis inhibitor. Arrests the cell cycle at G2/M phase. Promotes tubulin depolymerization. Induces fragmentation of the Golgi complex. Inhibits the T cell antigen receptor. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway. Apoptosis inducer. Autophagy inhibition through prevention of autophagosome-lysosome fusion.
More Information Supplier PageNegative control for protein kinase C (PKC) inhibitors. S6K inhibitor. Necrosis inhibitor.
More Information Supplier PageNegative control for protein kinase C (PKC) inhibitors. S6K inhibitor. Necrosis inhibitor.
More Information Supplier PagePotent and selective antagonist for mGluR5. 5-fold higher anxiolytic activity than MPEP. Antidepressant. Neuroprotective. Produces antiparkinsonian-like effects in rats.
More Information Supplier PagePotent and selective antagonist for mGluR5. 5-fold higher anxiolytic activity than MPEP. Antidepressant. Neuroprotective. Produces antiparkinsonian-like effects in rats.
More Information Supplier PageSelective leukotriene LTD4 receptor antagonist. Potent MRP1 inhibitor. Antinociceptive.
More Information Supplier PageSelective leukotriene LTD4 receptor antagonist. Potent MRP1 inhibitor. Antinociceptive.
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