AdipoGen Life Sciences
Adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 less potent than AdipoRon (Prod. No. AG-CR1-0154) http://www.adipogen.com/ag-cr1-0154/adiporon.html . Activates 5′-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms.
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AdipoGen Life Sciences
Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low µm concentration. Activates 5′-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by […]
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AdipoGen Life Sciences
Rapid apoptosis inducer that initiates intrinsic pathway caspase-dependent apoptosis within minutes in multiple cell lines and in vivo systems. Exerts anticancer activity in vivo, likely through the induction of apoptosis. Induces cell death against various cancer and non-cancerous cell lines with 24 hour IC50 values between 0.7-3.4µM indicating activity across a wide range of cell […]
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ODQ
10 mg
| >98%
AdipoGen Life Sciences
Potent and highly selective, irreversible inhibitor of soluble guanylyl cyclase (sGC). The binding is competitive with nitric oxide (NO). Tool to elucidate the nitric oxide (NO)-cGMP pathway. Apoptosis inhibitor Inhibits growth and migration of prostate cancer cells independent of its effects on GMP levels.
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SAG
1 mg
| >98%
AdipoGen Life Sciences
Cell permeable Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Induces Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations. Potent activator of VEGF expression in vitro.
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AdipoGen Life Sciences
Anticoagulant that retains platelets functionality. Buffers Ca2+ activity in physiological range (~1mM). Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response. Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its ‘high iron’ conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo […]
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AdipoGen Life Sciences
Anticoagulant that retains platelets functionality. Buffers Ca2+ activity in physiological range (~1mM). Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response. Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its ‘high iron’ conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo […]
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AdipoGen Life Sciences
Cell permeable and reversible kinesin-specific MKLP-2 (mitotic kinesin-like protein 2) inhibitor. Inhibits the recruitment of the chromosome passenger proteins survivin and aurora B to the central spindle during anaphase chromosome segregation. Moderate DYRK1A inhibitor (IC50= 5.5 µM). Lead compound.
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AdipoGen Life Sciences
Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitochondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth.
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Shz-1
5 mg
| >95%
AdipoGen Life Sciences
Enhancer of myocardial regenerative repair by stem cells. Potent inducer of Nkx2.5 and a subset of other cardiac markers, including myocardin, and sarcomeric-tropomyosin (SalphaTM) in a variety of different stem/progenitor cells.
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