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TPh A 1 mg  | >98%

AdipoGen Life Sciences

Nuclear protein pirin inhibitor. Inhibits the interaction between Bcl3 oncoprotein and the nuclear protein pirin. Melanoma cell migration inhibitor.

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SAG 5 mg  | >98%

AdipoGen Life Sciences

Cell permeable Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Induces Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations. Potent activator of VEGF expression in vitro.

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IBMX 500 mg  | >99%

AdipoGen Life Sciences

Cell permeable, competitive, non-specific cAMP and cGMP phosphodiesterase inhibitor. Increases cAMP levels that activate PKA, leading to decreased proliferation, increased differentiation and induction of apoptosis. Enhances differentiation of 3T3-L1 cells. Non-selective adenosine receptor antagonist. Inhibits Ca2+ ion channels. Activates TNF-alpha. Adipogenic. Activates leukotriene synthesis. Reduces inflammation and innate immunity.

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S14161 5 mg  | >99%

AdipoGen Life Sciences

Potent antileukemia and antimyeloma compound. Apoptosis inducer. Delays tumor growth. Cyclin D2 promoter transactivation inhibitor. Inhibitor of pan-Class I PI3K isoforms.

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S14161 1 mg  | >99%

AdipoGen Life Sciences

Potent antileukemia and antimyeloma compound. Apoptosis inducer. Delays tumor growth. Cyclin D2 promoter transactivation inhibitor. Inhibitor of pan-Class I PI3K isoforms.

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RO-3306 5 mg  | >95%

AdipoGen Life Sciences

Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M . Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Enhances Fas-mediated activation and processing of procaspase-8 […]

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RO-3306 1 mg  | >95%

AdipoGen Life Sciences

Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M . Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Enhances Fas-mediated activation and processing of procaspase-8 […]

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SANT-2 5 mg  | >95%

AdipoGen Life Sciences

Sonic hedgehog (Shh) signaling pathway modulator. Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. SAG activity (Prod. Nr. AG-CR1-3506) inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker.

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SANT-2 1 mg  | >95%

AdipoGen Life Sciences

Sonic hedgehog (Shh) signaling pathway modulator. Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. SAG activity (Prod. Nr. AG-CR1-3506) inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker.

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