Potent stimulator of invariant natural killer T (iNKT) cells. Induces strong antitumor immunity through a nitric oxide (NO) and TNF-alpha dependent mechansim, different compared to the IFN-gamma dependent mechanism of alpha-GalCer (AG-CN2-0014). Does not induce anergy of iNKT cells.
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Potent and highly selective Bruton’s tyrosine kinase (BTK) inhibitor. Orally bioavailable and irreversible inhibitor of BTK (IC50 = 0.5 nM) with antineoplastic activity. Binds to and irreversibly inhibits BTK activity, preventing B cell activation and B cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. Shown to […]
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Potent and highly selective Bruton’s tyrosine kinase (BTK) inhibitor. Orally bioavailable and irreversible inhibitor of BTK (IC50 = 0.5 nM) with antineoplastic activity. Binds to and irreversibly inhibits BTK activity, preventing B cell activation and B cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. Shown to […]
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Anticancer compound. Orally active, potent and selective colony stimulating factor 1 receptor (CSF-1R; c-Fms) inhibitor. More than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and platelet-derived growth factor receptor beta (PDGFRbeta). Selective against more than 200 additional kinases.
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Anticancer compound. Orally active, potent and selective colony stimulating factor 1 receptor (CSF-1R; c-Fms) inhibitor. More than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and platelet-derived growth factor receptor beta (PDGFRbeta). Selective against more than 200 additional kinases.
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Synthetic, soluble analog of alpha-galactosylceramide (Prod. No. AG-CN2-0013). Immunostimulant. Potent stimulator of natural killer T (NKT) cells. Specific ligand of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells.
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Bombesin receptor subtype-3 (BRS-3) agonist. Energy homeostasis regulator.
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Potent cyclooxygenase-2 (COX-2) inhibitor. Inhibits inflammatory prostaglandin E2 (PGE2) production.
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Non-cytotoxic melanogenesis inhibitor. Potential depigmentation agent. Tyrosinase-related protein 2 (TRP-2) expression inhibitor, via proteasomal degradation. Inhibits the proliferation of melanocytes and melanoma cells through cell cycle arrest in G1. Moderate skin tumor growth suppressor in vivo.
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Anticancer compound. Shown to inhibit progression of prostate cancer cells. Anti-obesity agent. 3T3-L1 adipocyte differentiation and FAS expression inhibitor.
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