Toll-like receptor 4 (TLR4) activator. Activates TLR4 but does not activate TLR2 even at high concentrations. Defined structure of MPLA. Synthetic lipid A is structurally very similar to natural MPLA but does not exist in nature.
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Water-soluble phosphate salt of Ruxolitinib. Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and […]
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Water-soluble phosphate salt of Ruxolitinib. Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and […]
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Human poly(ADP-ribose) glycohydrolase (PARG) inhibitor for in vitro studies. Inhibits human recombinant PARG enzymes (IC50=26nM) and PARG in cell assays (IC50=37nM). Inactive against related glycohydrolases ARH3 and PARP1s (IC50>30µM). Showed no cytotoxicity (IC50>30µM). Poly(ADP ribose) glycohydrolase (PARG) is a critical component in the repair of single strand DNA breaks and therefore a target in cancer […]
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Potent antioxidant. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavenger. Anti-cancer and anti-inflammatory compound. Aromatase activity inhibitor. Moderate cytotoxic against selected cancer cell lines.
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Antibiotic. Antimicrobial, anti-inflammatory, anticancer and immunosuppressive compound. Shown to have hepatoprotective and hypoglycemic activity. Apoptosis inducer in cancer cells. Sensitizes cancer cells. Induces cell cycle arrest. Antiviral agent. Inhibited influenza A viral infection and growth through activation of Nrf2. Inhibitor of protein tyrosine phosphatase 1B (PTB1B). Antioxidant. Inhibitor of mitochondrial lipid peroxidation. Inhibitor of inducible […]
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Antibiotic. Moderate antibacterial and antifungal agent. Inhibits the autophosphorylation of histidine kinase WalK/YycG. The WalK/WalR (aka YycG/YycF) two-component system is indispensable in the signal transduction pathway for the cell-wall metabolism/synthesis.
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Moderate inhibitor of selected kinases. Shows no cytotoxic activity in the MTT assay.
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Antifouling compound. Antimycobacterial and antibacterial agent. Exerts its antibacterial effect by inhibiting enzyme BCG 3185c, a suspected dioxygenase thereby disrupting bacterial homeostasis. Associated with contractive responses of smooth muscles and inhibition of Na+/K+ ATPase. Cytotoxic/Antineoplastic agent. Found to exhibit inhibitory activity against several cancer cell lines, including the drug resistant renal cancer cell line (ACHN). […]
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Metabolite of aloesin. Potent antioxidant (DPPH assay). Antibiotic. Antifungal. Moderate BACE inhibitor.
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