AdipoGen Life Sciences
Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer’s Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly […]
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AdipoGen Life Sciences
Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer’s Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly […]
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AdipoGen Life Sciences
Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer’s Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly […]
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AdipoGen Life Sciences
Azaphilone fungal metabolite. Induces formation of chlamydospore-like cells in fungi. Trypsin inhibitor (IC50=16µg/ml). Mitorubrinic acid was shown to be a virulence factor of Penicillium marneffei by improving its intracellular survival in macrophages. P. marneffei is the most important thermal dimorphic fungus causing respiratory, skin and systemic mycosis in China and Southeast Asia. It is a […]
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AdipoGen Life Sciences
Cell permeable mycotoxin. Actin polymerization inhibitor. Binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments. Induces nuclear extrusion. By disrupting actin polymerization, blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis and chemotaxis. Induces DNA fragmentation. Used in cytoskeletal reorganization, cell imaging and organelle trafficking studies. Potent […]
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AdipoGen Life Sciences
Cell permeable mycotoxin. Actin polymerization inhibitor. Binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments. Induces nuclear extrusion. By disrupting actin polymerization, blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis and chemotaxis. Induces DNA fragmentation. Used in cytoskeletal reorganization, cell imaging and organelle trafficking studies. Potent […]
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AdipoGen Life Sciences
Inhibitor of CDK5/p25 (IC50=4µM) and GSK-3beta (IC50=12µM). Potentially useful in neuronal diseases research. Antagonist of serotonergic receptors. Shown to reduce voltage-dependent calcium elevation. Moderate anticancer compound. Inhibits cell growth in a panel of cancer cell lines at low µM range. Antiprotozoal agent. Antibacterial. Plays a role in the sponge antibacterial defense.
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AdipoGen Life Sciences
Antioxidant. Reactive oxygen species (ROS) scavenger. Specific ligand of the coactivator CBP/p300, binding to the GACKIX domain. Efficiently inhibits binding of activators at two binding sites. Antibiotic. Potent antibacterial compound. Antifungal on selected fungi species. Antiviral agent. Interferes with the viral replication of selected respiratory syncytial virus. Competitive alpha-glucosidase and non-competitive beta-glucosidase inhibitor. Shows moderate […]
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AdipoGen Life Sciences
Anti-inflammatory compound. Potent dual inhibitor of pro-inflammatory transcription factors and inflammatory enzymes. Inhibitor of NFkappaB activation. Potent inhibitor of inducible microsomal prostaglandin E2 synthase-1 (mPGES-1), the terminal synthase responsible for the synthesis of the pro-tumorigenic prostaglandin E2 (PGE2). Antioxidant. 5-Lipoxygenase (5-LO) inhibitor. Antibacterial compound. HIV-1 replication inhibitor.
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