Antibiotic. Topoisomerase II inhibitor. Mediates a unique cross-linking reaction between DNA and histidine H3. Anti-neoplastic. Photosensitizing compound. Antitumor compound against human cell lines.
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Macrolide antibiotic. Bacterial, protozoan and mammalian threonyl-tRNA synthetase (THrRS) inhibitor. Antiangiogenic (IC50 = 0.8 nM) and anticancer agent. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Blocks the formation of spontaneous lung […]
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Antibiotic. Specific vacuolar-type H+-ATPase inhibitor. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Antibacterial, antifungal, insecticidal and anthelmintic. Potential anti-osteoporotic agent in treating bone lytic diseases. Neuroprotection inducer.
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Antifungal. Cytotoxic against some tumor cell lines, partly attributed to inhibition of Ras-inducible genes. Inhibits proliferation of mouse and human T cells. Modulates production of cytokines during T cell activation. Facilitates the ubiquitinylation process of cyclin D1. Potent and selective threonine/tyrosine-specific kinase, MEK and other protein kinases inhibitor in both in vitro and in vivo […]
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Antifungal. Cytotoxic against some tumor cell lines, partly attributed to inhibition of Ras-inducible genes. Inhibits proliferation of mouse and human T cells. Modulates production of cytokines during T cell activation. Facilitates the ubiquitinylation process of cyclin D1. Potent and selective threonine/tyrosine-specific kinase, MEK and other protein kinases inhibitor in both in vitro and in vivo […]
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Spirobisnaphthalene derivative (unpublished). Oxidation product of palmarumycin C3. This compound has not yet been thoroughly tested for its biological activity.
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Spirobisnaphthalene derivative (unpublished). Oxidation product of palmarumycin C3. This compound has not yet been thoroughly tested for its biological activity.
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Antibiotic. Antibacterial and antifungal. Antitumor compound. Germination inhibitor.
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