Antibiotic. Inhibitor of HIF-1 formation by disrupting the binding of p300 to both HIF-1alpha and HIF-2alpha. Histone H3K9 methyltransferases G9a and Suv39h inhibitor. Tumor growth inhibitor. Angiogenesis inhibitor. Potent immunosuppressor. Antibacterial and antifungal. Strong inducer of retinal pigment epithelium (RPE).
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Derivative of the farnesyltransferase inhibitor Manumycin A (Prod. No. BVT-0091 http://www.adipogen.com/bvt-0091/manumycin-a.html ). This compound has not yet been thoroughly tested for its biological activity.
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Derivative of the farnesyltransferase inhibitor Manumycin A (Prod. No. BVT-0091 http://www.adipogen.com/bvt-0091/manumycin-a.html ). This compound has not yet been thoroughly tested for its biological activity.
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Antibiotic. Shows weak cytotoxic activity against different tumor cell lines. Shows antiparasitic activity.
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Antibiotic. Shows weak cytotoxic activity against different tumor cell lines. Shows antiparasitic activity.
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Antibiotic. Cytochalasan analog with anti-fungal activity. Phytotoxic, nematicidal and anti-bacterial activity. Exhibits cytotoxic effects against human cancer cell lines. Induces apoptosis in lymphocytic leukemia cells by targeting the cytoskeleton. Enhances fibrinolytic activity of bovine aortic endothelial cells. Mycotoxin.
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Antibiotic. Cytochalasan analog with anti-fungal activity. Phytotoxic, nematicidal and anti-bacterial activity. Exhibits cytotoxic effects against human cancer cell lines. Induces apoptosis in lymphocytic leukemia cells by targeting the cytoskeleton. Enhances fibrinolytic activity of bovine aortic endothelial cells. Mycotoxin.
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Antibiotic. Apoptosis and endoplasmic reticulum stress-mediated cell death inducer. Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM). Does not affect geranylgeranyltransferase (IC50 = 180 µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Neutral sphingomyelinase inhibitor. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes […]
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Antibiotic. Apoptosis and endoplasmic reticulum stress-mediated cell death inducer. Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM). Does not affect geranylgeranyltransferase (IC50 = 180 µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Neutral sphingomyelinase inhibitor. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes […]
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