Antibiotic against Gram-positive bacteria, particularly Staphylococcus and Clostridia. More effective against multi-resistant strains (MRSA) than erythromycin and vancomycin. Inhibits cell proliferation and induces HL-60 cell differentiation in combination with 1,25-Dihydroxyvitamin-D3 and ATRA. Displays low cytotoxicity compared to erythromycin and spiramycin.
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Antibiotic. Isomeric to thiotropocin. Antibacterial. Active against Gram-positive and Gram-negative bacteria. Antifungal and anti-nematodical. Shows antitumor activity. Cytotoxic against selected mammalian neuronal cell lines. Bacterial signal substance.
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Antibiotic. Isomeric to thiotropocin. Antibacterial. Active against Gram-positive and Gram-negative bacteria. Antifungal and anti-nematodical. Shows antitumor activity. Cytotoxic against selected mammalian neuronal cell lines. Bacterial signal substance.
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Antibiotic. Antibacterial, antifungal and antiprotozoal. Cytotoxic against several tumor cell lines in vitro.
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Antibiotic. Antibacterial, antifungal and antiprotozoal. Cytotoxic against several tumor cell lines in vitro.
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Antibiotic. Weak topoisomerase I (Topo I) inhibitor. Structurally similar to staurosporine. Does not show any inhibitory activity against protein kinases. Shows significant antitumor properties in vitro (IC50 = 480 nM against mouse B16 melanoma cells and IC50 = 500 nM against P388 leukemia cells).
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Antibiotic. Weak topoisomerase I (Topo I) inhibitor. Structurally similar to staurosporine. Does not show any inhibitory activity against protein kinases. Shows significant antitumor properties in vitro (IC50 = 480 nM against mouse B16 melanoma cells and IC50 = 500 nM against P388 leukemia cells).
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alpha-Glucosidase inhibitor. Inhibitor of glycoprotein processing. Strong glycosyltransferase (GTF) inhibitor. Angiogenesis inhibitor. Reduces the size of myocardial infarcts.
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