ADCs Toxins, Phytosphingosine is a sphingolipid endogenous to many organisms involved in cell signaling. Phytosphingosine displays anbibacterial activity (CL Fischer et al. Antimicrob. Agents Chemother. 2012 56:1157). Phytosphingosine can be taken up by E. coli and S. aureus and induce ultrastrucural damag (CL Fischer et al. Skin Pharmacol. Physiol. 2013 26:36). IC 50 value: Jurkat […]
More Information Supplier PageADCs Toxins, Phalloidin is a bicyclic heptapeptide toxin of the death cap mushroom toxin family aslo called phallotoxins. Phalloidin binds F-actin, preventing its depolymerization and is poisoning the cell. It specially binds at the inferface between F-acting subunits, locking adjacetn subunits togeter. Phalloidin binds specifically to polymeric and oligomeric forms of actin and not to […]
More Information Supplier PageADCs Toxins, Phallacidin is a bicyclic toxin from the Amanita phalloides mushroom. Phallacidin inhibits F-acting degradation by proteolytic enzymes including trypsin and alpha-chymotrypsin. Phallacidin is extracted i.e. from Amanita phalloides.
More Information Supplier PageADCs Toxins, Oligomycin B is a macrolide antibiotic that inhibits membrane bound mitochondrial ATPase and which is practically free of homologs. Oligomycin B inhibits the growth of Rhodotorula gultinis, Aspergillus niger and other moulds. Origin: Streptomyces diastatochromogenes. HCT-116: IC50=0,0012 uM; PSN1 : IC50=1,24 uM; T98G : IC50=6,21 uM; A549 : IC50=6,21 uM (preliminary laboratory results).
More Information Supplier PageADCs Toxins, Okilactomycin is a novel antibiotic produced by a Streptomyces species. HCT-116: IC50=0,002 uM; PSN1 : IC50=0,120 uM; T98G : IC50=0,240 uM; A549 : IC50=0,240 uM (preliminary laboratory results). Journal of Antibiotics (1987), 40, 1475-82.
More Information Supplier PageADCs Toxins, beta-Amanitin, a cyclic peptide, consisting of eight amino acids is part of the toxic peptide group of the Amanita phalloides mushroom. beta-Amanitin inhibits mammalian protein synthesis.It is an inhibitor of RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase.
More Information Supplier PageADCs Toxins, Microtubule stabilization agent that promotes tubulin polymerization and induces G2-M cell cycle arrest. Inhibits a variety of human cancer cell lines, including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent anticancer activity in numerous human tumor xenografts in vivo. Epothilone B is a Tubulin inhibitor.
More Information Supplier PageADCs Toxins, (-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.
More Information Supplier PageADCs Toxins, Dolastatin 15 may be a useful tubulin-targeting payload for the conjugation at various antibody reactive sites, depending on the used linker technology. IC50 value 23 µM (Bai et al. 1992). Dolastatin 15 is a Tubulin inhibitor.
More Information Supplier PageADCs Toxins, Used in molecular biology. DTT preserves proteins of interiors of cells in their functional form by avoiding the oxidation of Sulfhidril-groups (SH-) into disulifidbridges through atmospheric oxygen. On the other hand the convolution of proteins whose structure is stabilised by disulfidbridges may be destroyed by their reduction. It is an important reagent in […]
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