Creative Biolabs
ADCs Toxins, alpha-Amanitin, a cyclic peptide, consisting of eight amino acids.The source of this specific alpha-Amanitin is fungal fermentation. By this production method the supply problems are solved. alpha-Amanitin is an inhibitor of RNA polymerase II (0.02 micrograms/ml). RNA polymerase I was also inhibited by the relatively high concentration of alpha-amanitin (IC50 = 100 micrograms/ml […]
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Creative Biolabs
ADCs Toxins, Lactacystin is a cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Lactacystin induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported […]
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JW 55
1 mg
| >95%
Creative Biolabs
ADCs Toxins, JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). The JW 55 activity results in stabilization of Axin2 and increased degradation of β-catenin.It inhibits the β-catenin signaling pathway. JW 55 has also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines.
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Creative Biolabs
ADCs Toxins, Ixabepilone is an epothilone B analog and microtubule-stabilizing agent. Ixabepilone showed potent induction of tubulin polymerization with an EC50 value of 3.5 µM
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Creative Biolabs
ADCs Toxins, Cytotoxic molecule. HCT-116: IC50=0,0019 uM; PSN1 : IC50=0,0019 uM; T98G : IC50=0,0019 uM; A549 : IC50=0,0019 uM (preliminary laboratory results).
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Creative Biolabs
ADCs Toxins, Calicheamicins are a group of enediyne antitumor antibiotics. Calicheamicins target DNA and cause strand scission.
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Creative Biolabs
ADCs Toxins, Polyketomycin is a tetracyclic quinone glycoside. Polyketomycin shows antibacterial, antimalarial and antitumor activity.
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Creative Biolabs
Creative Biolabs
ADCs Toxins, Pironetin is a potent inhibitor of tubulin. Pironetin covalently binds tubulin. Systematic alanine scanning shows, that the pironetin binding site was determined to be Lys352 of alpha-tubulin. Lys352 is located at the entrance of a small pocket of alpha-tubulin, and this pocket faces the beta-tubulin of the next dimer. This is the first […]
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Creative Biolabs
ADCs Toxins, Potent inhibitor of the mitochondrial and bacterial type I NADH-ubiquinone oxireductase. HCT-116: IC50=0,020 uM; PSN1 : IC50=12,03 uM; T98G : IC50=>12,03 uM; A549 : IC50=>12,03 uM (preliminary laboratory results). Journal of cellular physiology (2008), 215(1), 243-50.
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